AdipoRon|cas 924416-43-3| DC Chem|Supplier|Price|Buy  

AdipoRon|cas 924416-43-3| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AdipoRon|cas 924416-43-3,Purity: >98% ,Cat No. DC7049, In stock.

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AdipoRon|cas 924416-43-3 ,Synonym:  ,Chemical name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide ,Molecular Formula: C27H28N2O3 ,MW:428.52

AdipoRon, cas 924416-43-3,Purity: >98%, Best Price and quality from DC Chemicals. AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM).

AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes. [1] In skeletal muscle and liver of wild-type mice AdipoRon (50?mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50?mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet. [1]