Vacquinol-1|NSC 13316|DC Chemicals

Vacquinol-1|NSC 13316|DC Chemicals

Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.

Product Name: Vacquinol-1 |Catalog Number: DC8473 |CAS 5428-80-8 |Other names: NSC 13316,NSC13316,NSC-13316,Vacquinol 1,Vacquinol1 |Chemical Name: 2-(4-chlorophenyl)-α-2-piperidinyl-4-quinolinemethanol |Molecule Formular: C21H21ClN2O |MW: 352.9

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture.A key effector of vacquinols is MAPK kinase 4 (MKK4).1 Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.It induces ATP depletion in glioblastoma cells (IC50 = 3.14 µM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics.Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

For research and scientific purpose only, not for human use.