Rucaparib(AG-014447)|PARP-1 inhibitor|DC Chemicals

Rucaparib(AG-014447)|PARP-1 inhibitor|DC Chemicals

Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM.

Product Name: Rucaparib(AG-014447) |Catalog Number: DC8464 |CAS 283173-50-2 |Other names: AG 014447,AG014447 |Chemical Name: 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one |Molecule Formular: C19H18FN3O |MW: 323.4

Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM.7 At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors.It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts.

For research and scientific purpose only, not for human use.