A-1210477|A1210477|MCL-1 inhibitor|DC Chemicals

A-1210477|A1210477|MCL-1 inhibitor|DC Chemicals

A-1210477 is a potent and selective MCL-1 inhibitor.

Product Name: A-1210477 |Catalog Number: DC8475 |CAS 1668553-26-1 |Other names: A-1210477,A 1210477,A1210477 |Chemical Name: 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid |Molecule Formular: C46H55N7O7S |MW: 850.04

A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines. A-1210477 synergizes with the BCL-2/BCL-XL inhibitor navitoclax to kill a variety of cancer cell lines. A-1210477 is a potential therapeutics for the treatment of cancer. The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target.

For research and scientific purpose only, not for human use.