Tenovin-2 supplier|Tenovin2|DC Chemicals
DC Chemicals provides Tenovin-2, other names: Tenovin 2，Tenovin2, cas: . In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643303；
Tenovin-2, other names: Tenovin 2，Tenovin2, cas: , Molecule formular: C22H27N3O2S, Molecule Weight: 397.18, Chemical name: N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide hydrochloride (1:1)
For the detailed information of Tenovin-2, the solubility of Tenovin-2 in water, the solubility of Tenovin-2 in DMSO, the solubility of Tenovin-2 in PBS buffer, the animal experiment (test) of Tenovin-2, the cell expriment (test) of Tenovin-2, the in vivo, in vitro and clinical trial test of Tenovin-2, the EC50, IC50,and affinity,of Tenovin-2, Please contact DC Chemicals.
2015年3月31日星期二
2,4-Pyrimidinediamine with linker supplier|DC Chemicals
2,4-Pyrimidinediamine with linker supplier|DC Chemicals
DC Chemicals provides 2,4-Pyrimidinediamine with linker, other names: 2,4-Pyrimidinediamine with linker, cas: 1430089-64-7. In stock.
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2,4-Pyrimidinediamine with linker is a patent compound in WO2013055780A1, Page 71; multikinase inhibitor and has a -NH2 terminal linker for further synthesis.
2,4-Pyrimidinediamine with linker, other names: 2,4-Pyrimidinediamine with linker, cas: 1430089-64-7, Molecule formular: C19H24N8, Molecule Weight: 364.45, Chemical name:
2,4-Pyrimidinediamine with linker is a patent compound in WO2013055780A1, Page 71; multikinase inhibitor and has a -NH2 terminal linker for further synthesis. For the detailed information of 2,4-Pyrimidinediamine with linker, the solubility of 2,4-Pyrimidinediamine with linker in water, the solubility of 2,4-Pyrimidinediamine with linker in DMSO, the solubility of 2,4-Pyrimidinediamine with linker in PBS buffer, the animal experiment (test) of 2,4-Pyrimidinediamine with linker, the cell expriment (test) of 2,4-Pyrimidinediamine with linker, the in vivo, in vitro and clinical trial test of 2,4-Pyrimidinediamine with linker, the EC50, IC50,and affinity,of 2,4-Pyrimidinediamine with linker, Please contact DC Chemicals.
DC Chemicals provides 2,4-Pyrimidinediamine with linker, other names: 2,4-Pyrimidinediamine with linker, cas: 1430089-64-7. In stock.
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Tel: +86-21-58447131;Fax:+86-21-61643302；
2,4-Pyrimidinediamine with linker is a patent compound in WO2013055780A1, Page 71; multikinase inhibitor and has a -NH2 terminal linker for further synthesis.
2,4-Pyrimidinediamine with linker, other names: 2,4-Pyrimidinediamine with linker, cas: 1430089-64-7, Molecule formular: C19H24N8, Molecule Weight: 364.45, Chemical name:
2,4-Pyrimidinediamine with linker is a patent compound in WO2013055780A1, Page 71; multikinase inhibitor and has a -NH2 terminal linker for further synthesis. For the detailed information of 2,4-Pyrimidinediamine with linker, the solubility of 2,4-Pyrimidinediamine with linker in water, the solubility of 2,4-Pyrimidinediamine with linker in DMSO, the solubility of 2,4-Pyrimidinediamine with linker in PBS buffer, the animal experiment (test) of 2,4-Pyrimidinediamine with linker, the cell expriment (test) of 2,4-Pyrimidinediamine with linker, the in vivo, in vitro and clinical trial test of 2,4-Pyrimidinediamine with linker, the EC50, IC50,and affinity,of 2,4-Pyrimidinediamine with linker, Please contact DC Chemicals.
PF-06447475 supplier|PF06447475|DC Chemicals
PF-06447475 supplier|PF06447475|DC Chemicals
DC Chemicals provides PF-06447475, other names: PF 06447475，PF06447475, cas: 1527473-33-1. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643301；
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
PF-06447475, other names: PF 06447475，PF06447475, cas: 1527473-33-1, Molecule formular: C17H15N5O, Molecule Weight: 305.33, Chemical name:
PF-06447475 was sufficiently potent in the LRRK2 whole cell assay (WCA; IC50=25 nM) (pS935 end point) to warrant additional profiling. Oral administration of PF-06447475 twice daily for 15 days was well tolerated at doses up to 60 mg kg-1 day-1 (31-fold Cave,0.24h; 70-fold Cmax) with only minimal alterations in RBC parameters, electrolytes, and food consumption without concurrent effects on body weight.
For the detailed information of PF-06447475, the solubility of PF-06447475 in water, the solubility of PF-06447475 in DMSO, the solubility of PF-06447475 in PBS buffer, the animal experiment (test) of PF-06447475, the cell expriment (test) of PF-06447475, the in vivo, in vitro and clinical trial test of PF-06447475, the EC50, IC50,and affinity,of PF-06447475, Please contact DC Chemicals.
DC Chemicals provides PF-06447475, other names: PF 06447475，PF06447475, cas: 1527473-33-1. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643301；
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
PF-06447475, other names: PF 06447475，PF06447475, cas: 1527473-33-1, Molecule formular: C17H15N5O, Molecule Weight: 305.33, Chemical name:
PF-06447475 was sufficiently potent in the LRRK2 whole cell assay (WCA; IC50=25 nM) (pS935 end point) to warrant additional profiling. Oral administration of PF-06447475 twice daily for 15 days was well tolerated at doses up to 60 mg kg-1 day-1 (31-fold Cave,0.24h; 70-fold Cmax) with only minimal alterations in RBC parameters, electrolytes, and food consumption without concurrent effects on body weight.
For the detailed information of PF-06447475, the solubility of PF-06447475 in water, the solubility of PF-06447475 in DMSO, the solubility of PF-06447475 in PBS buffer, the animal experiment (test) of PF-06447475, the cell expriment (test) of PF-06447475, the in vivo, in vitro and clinical trial test of PF-06447475, the EC50, IC50,and affinity,of PF-06447475, Please contact DC Chemicals.
ACT058362 (Palosuran)supplier|ACT-058362|DC Chemicals
ACT058362 (Palosuran)supplier|ACT-058362|DC Chemicals
DC Chemicals provides ACT058362 (Palosuran), other names: ACT058362，ACT-058362, cas: 540769-28-6. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643300；
Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.
ACT058362 (Palosuran), other names: ACT058362，ACT-058362, cas: 540769-28-6, Molecule formular: C25H30N4O2, Molecule Weight: 418.53, Chemical name: Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
Palosuran inhibited 125I-U-II binding to human UT receptors in membrane preparations from CHO cells carrying the human UT receptors almost as potently as cold U-II, with an IC50 of 3.6 ± 0.2 nM. On cells, the inhibitory binding potency of palosuran against human UT receptor was lower than on membranes (IC50 = 46.2 ± 13 nM on TE 671 cells and 86 ± 30 nM on recombinant CHO cells). Compared with the human UT receptor, the binding inhibitory potency of palosuran against the rat UT receptor was lower in membrane preparation (400-fold), as well as in cells (>120-fold) For the detailed information of ACT058362 (Palosuran), the solubility of ACT058362 (Palosuran) in water, the solubility of ACT058362 (Palosuran) in DMSO, the solubility of ACT058362 (Palosuran) in PBS buffer, the animal experiment (test) of ACT058362 (Palosuran), the cell expriment (test) of ACT058362 (Palosuran), the in vivo, in vitro and clinical trial test of ACT058362 (Palosuran), the EC50, IC50,and affinity,of ACT058362 (Palosuran), Please contact DC Chemicals.
DC Chemicals provides ACT058362 (Palosuran), other names: ACT058362，ACT-058362, cas: 540769-28-6. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643300；
Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.
ACT058362 (Palosuran), other names: ACT058362，ACT-058362, cas: 540769-28-6, Molecule formular: C25H30N4O2, Molecule Weight: 418.53, Chemical name: Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
Palosuran inhibited 125I-U-II binding to human UT receptors in membrane preparations from CHO cells carrying the human UT receptors almost as potently as cold U-II, with an IC50 of 3.6 ± 0.2 nM. On cells, the inhibitory binding potency of palosuran against human UT receptor was lower than on membranes (IC50 = 46.2 ± 13 nM on TE 671 cells and 86 ± 30 nM on recombinant CHO cells). Compared with the human UT receptor, the binding inhibitory potency of palosuran against the rat UT receptor was lower in membrane preparation (400-fold), as well as in cells (>120-fold) For the detailed information of ACT058362 (Palosuran), the solubility of ACT058362 (Palosuran) in water, the solubility of ACT058362 (Palosuran) in DMSO, the solubility of ACT058362 (Palosuran) in PBS buffer, the animal experiment (test) of ACT058362 (Palosuran), the cell expriment (test) of ACT058362 (Palosuran), the in vivo, in vitro and clinical trial test of ACT058362 (Palosuran), the EC50, IC50,and affinity,of ACT058362 (Palosuran), Please contact DC Chemicals.
PS-1145 supplier|PS1145|DC Chemicals
PS-1145 supplier|PS1145|DC Chemicals
DC Chemicals provides PS-1145, other names: PS 1145，PS1145, cas: 431898-65-6. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643299；
PS-1145 has been shown to be an IKK (IKB kinase) inhibitor.
PS-1145, other names: PS 1145，PS1145, cas: 431898-65-6, Molecule formular: , Molecule Weight: , Chemical name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
PS-1145 has been shown to be an IKK (IKB kinase) inhibitor. For the detailed information of PS-1145, the solubility of PS-1145 in water, the solubility of PS-1145 in DMSO, the solubility of PS-1145 in PBS buffer, the animal experiment (test) of PS-1145, the cell expriment (test) of PS-1145, the in vivo, in vitro and clinical trial test of PS-1145, the EC50, IC50,and affinity,of PS-1145, Please contact DC Chemicals.
DC Chemicals provides PS-1145, other names: PS 1145，PS1145, cas: 431898-65-6. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643299；
PS-1145 has been shown to be an IKK (IKB kinase) inhibitor.
PS-1145, other names: PS 1145，PS1145, cas: 431898-65-6, Molecule formular: , Molecule Weight: , Chemical name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
PS-1145 has been shown to be an IKK (IKB kinase) inhibitor. For the detailed information of PS-1145, the solubility of PS-1145 in water, the solubility of PS-1145 in DMSO, the solubility of PS-1145 in PBS buffer, the animal experiment (test) of PS-1145, the cell expriment (test) of PS-1145, the in vivo, in vitro and clinical trial test of PS-1145, the EC50, IC50,and affinity,of PS-1145, Please contact DC Chemicals.
IDO Inhibitor 1 supplier||DC Chemicals
IDO Inhibitor 1 supplier||DC Chemicals
DC Chemicals provides IDO Inhibitor 1, other names: , cas: 1204669-37-3. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643298；
IDO inhibitor1 is a potent and novel indoleamine-2,3 dioxygenase (ISO)inhibitor with an IC 50 value <100 nM.
IDO Inhibitor 1, other names: , cas: 1204669-37-3, Molecule formular: C11H13BrFN7O4S, Molecule Weight: 438.23, Chemical name:
IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. For the detailed information of IDO Inhibitor 1, the solubility of IDO Inhibitor 1 in water, the solubility of IDO Inhibitor 1 in DMSO, the solubility of IDO Inhibitor 1 in PBS buffer, the animal experiment (test) of IDO Inhibitor 1, the cell expriment (test) of IDO Inhibitor 1, the in vivo, in vitro and clinical trial test of IDO Inhibitor 1, the EC50, IC50,and affinity,of IDO Inhibitor 1, Please contact DC Chemicals.
DC Chemicals provides IDO Inhibitor 1, other names: , cas: 1204669-37-3. In stock.
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Tel: +86-21-58447131;Fax:+86-21-61643298；
IDO inhibitor1 is a potent and novel indoleamine-2,3 dioxygenase (ISO)inhibitor with an IC 50 value <100 nM.
IDO Inhibitor 1, other names: , cas: 1204669-37-3, Molecule formular: C11H13BrFN7O4S, Molecule Weight: 438.23, Chemical name:
IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. For the detailed information of IDO Inhibitor 1, the solubility of IDO Inhibitor 1 in water, the solubility of IDO Inhibitor 1 in DMSO, the solubility of IDO Inhibitor 1 in PBS buffer, the animal experiment (test) of IDO Inhibitor 1, the cell expriment (test) of IDO Inhibitor 1, the in vivo, in vitro and clinical trial test of IDO Inhibitor 1, the EC50, IC50,and affinity,of IDO Inhibitor 1, Please contact DC Chemicals.
calpeptin supplier||DC Chemicals
calpeptin supplier||DC Chemicals
DC Chemicals provides calpeptin, other names: , cas: 117591-20-5. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643297；
calpeptin is Ca2+-dependent protease,calpain inhibitor
DC Chemicals provides calpeptin, other names: , cas: 117591-20-5. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643297；
calpeptin is Ca2+-dependent protease,calpain inhibitor
calpeptin, other names: , cas: 117591-20-5, Molecule formular: , Molecule Weight: , Chemical name: benzyl N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]carbamate
Calpeptin is a cell permeable calpain inhibitor. Research shows that Calpeptin is an effective inhibitor of calpain 2 and can fully block cleavage of PLC-β 3 enzymes. Additionally, Calpeptin has demonstrated the ability to inhibit the activities of cathepsin L and calpain-1. In muscle cell studies Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. Pulmonary fibrosis research in mice have reported that Calpeptin can decrease expression of TGF-β1, IL-6, collage type Iα1, and angiopoietin-1 mRNA. Calpeptin is an inhibitor of Calpain 1, cathepsin K, cathepsin L and PTP. Calpeptin is an activator of Rock. For the detailed information of calpeptin, the solubility of calpeptin in water, the solubility of calpeptin in DMSO, the solubility of calpeptin in PBS buffer, the animal experiment (test) of calpeptin, the cell expriment (test) of calpeptin, the in vivo, in vitro and clinical trial test of calpeptin, the EC50, IC50,and affinity,of calpeptin, Please contact DC Chemicals.
U73122 supplier|U-73122|DC Chemicals
U73122 supplier|U-73122|DC Chemicals
DC Chemicals provides U73122, other names: U 73122，U-73122, cas: 112648-68-7. In stock.
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Tel: +86-21-58447131;Fax:+86-21-61643296；
U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).
U73122, other names: U 73122，U-73122, cas: 112648-68-7, Molecule formular: C29H40N2O3, Molecule Weight: 464.64, Chemical name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione
In neutrophils and human platelets, U-73122 inhibits agonist-induced phospholipase C (IC50=1.0-2.1 μM) activation. This compound affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. In SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73122 is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences. For the detailed information of U73122, the solubility of U73122 in water, the solubility of U73122 in DMSO, the solubility of U73122 in PBS buffer, the animal experiment (test) of U73122, the cell expriment (test) of U73122, the in vivo, in vitro and clinical trial test of U73122, the EC50, IC50,and affinity,of U73122, Please contact DC Chemicals.
DC Chemicals provides U73122, other names: U 73122，U-73122, cas: 112648-68-7. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643296；
U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).
U73122, other names: U 73122，U-73122, cas: 112648-68-7, Molecule formular: C29H40N2O3, Molecule Weight: 464.64, Chemical name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione
In neutrophils and human platelets, U-73122 inhibits agonist-induced phospholipase C (IC50=1.0-2.1 μM) activation. This compound affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. In SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73122 is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences. For the detailed information of U73122, the solubility of U73122 in water, the solubility of U73122 in DMSO, the solubility of U73122 in PBS buffer, the animal experiment (test) of U73122, the cell expriment (test) of U73122, the in vivo, in vitro and clinical trial test of U73122, the EC50, IC50,and affinity,of U73122, Please contact DC Chemicals.
SBE 13 hydrochloride supplier||DC Chemicals
SBE 13 hydrochloride supplier||DC Chemicals
DC Chemicals provides SBE 13 hydrochloride, other names: , cas: 1052532-15-6. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643295；
SBE13 Hcl is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.
SBE 13 hydrochloride, other names: , cas: 1052532-15-6, Molecule formular: C24H28Cl2N2O4, Molecule Weight: 479.4, Chemical name: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
To test the selectivity of SBE13 for Plk1 we probed its inhibitory effect on aurora A kinase, Plk2, and Plk3. No decrease in aurora A kinase activity was observed, and only marginally decreased Plk2 (IC50>66μm) or Plk3 (IC50=875 nm) kinase activity was detected after 13 h release in the presence of SBE13 (p>0.05) [1]. Plk1 inhibition using SBE13 enhances the effects of Enzastaurin in cancer cells. HCT116(p53wt) and HCT116(p53-/-) cells confirmed the p53-dependence of different effects after Plk1 and PKCβ inhibition observed in HeLa and MCF-7 cells. Obviously, p53 protects cells from the cytotoxicity of Enzastaurin in combination with SBE13 For the detailed information of SBE 13 hydrochloride, the solubility of SBE 13 hydrochloride in water, the solubility of SBE 13 hydrochloride in DMSO, the solubility of SBE 13 hydrochloride in PBS buffer, the animal experiment (test) of SBE 13 hydrochloride, the cell expriment (test) of SBE 13 hydrochloride, the in vivo, in vitro and clinical trial test of SBE 13 hydrochloride, the EC50, IC50,and affinity,of SBE 13 hydrochloride, Please contact DC Chemicals.
DC Chemicals provides SBE 13 hydrochloride, other names: , cas: 1052532-15-6. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643295；
SBE13 Hcl is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.
SBE 13 hydrochloride, other names: , cas: 1052532-15-6, Molecule formular: C24H28Cl2N2O4, Molecule Weight: 479.4, Chemical name: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
To test the selectivity of SBE13 for Plk1 we probed its inhibitory effect on aurora A kinase, Plk2, and Plk3. No decrease in aurora A kinase activity was observed, and only marginally decreased Plk2 (IC50>66μm) or Plk3 (IC50=875 nm) kinase activity was detected after 13 h release in the presence of SBE13 (p>0.05) [1]. Plk1 inhibition using SBE13 enhances the effects of Enzastaurin in cancer cells. HCT116(p53wt) and HCT116(p53-/-) cells confirmed the p53-dependence of different effects after Plk1 and PKCβ inhibition observed in HeLa and MCF-7 cells. Obviously, p53 protects cells from the cytotoxicity of Enzastaurin in combination with SBE13 For the detailed information of SBE 13 hydrochloride, the solubility of SBE 13 hydrochloride in water, the solubility of SBE 13 hydrochloride in DMSO, the solubility of SBE 13 hydrochloride in PBS buffer, the animal experiment (test) of SBE 13 hydrochloride, the cell expriment (test) of SBE 13 hydrochloride, the in vivo, in vitro and clinical trial test of SBE 13 hydrochloride, the EC50, IC50,and affinity,of SBE 13 hydrochloride, Please contact DC Chemicals.
Aurora A Inhibitor I supplier||DC Chemicals
Aurora A Inhibitor I supplier||DC Chemicals
DC Chemicals provides Aurora A Inhibitor I, other names: , cas: 1158838-45-9. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643294；
Aurora A inhibitor I is a selective Aurora A inhibitor (Aurora A: IC50=0.0034 μM; Aurora B IC50=3.4 μM), (B/A ratio=1000).
Aurora A Inhibitor I, other names: , cas: 1158838-45-9, Molecule formular: C31H31ClFN7O2, Molecule Weight: 588.08, Chemical name: N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide
Aurora A inhibitor I is an exceptionally selective Aurora A inhibitor; we can see no indications in cellular assays that it inhibits Aurora B or CDKs. As such, it is a useful tool compound for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B. For the detailed information of Aurora A Inhibitor I, the solubility of Aurora A Inhibitor I in water, the solubility of Aurora A Inhibitor I in DMSO, the solubility of Aurora A Inhibitor I in PBS buffer, the animal experiment (test) of Aurora A Inhibitor I, the cell expriment (test) of Aurora A Inhibitor I, the in vivo, in vitro and clinical trial test of Aurora A Inhibitor I, the EC50, IC50,and affinity,of Aurora A Inhibitor I, Please contact DC Chemicals.
DC Chemicals provides Aurora A Inhibitor I, other names: , cas: 1158838-45-9. In stock.
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Tel: +86-21-58447131;Fax:+86-21-61643294；
Aurora A inhibitor I is a selective Aurora A inhibitor (Aurora A: IC50=0.0034 μM; Aurora B IC50=3.4 μM), (B/A ratio=1000).
Aurora A Inhibitor I, other names: , cas: 1158838-45-9, Molecule formular: C31H31ClFN7O2, Molecule Weight: 588.08, Chemical name: N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide
Aurora A inhibitor I is an exceptionally selective Aurora A inhibitor; we can see no indications in cellular assays that it inhibits Aurora B or CDKs. As such, it is a useful tool compound for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B. For the detailed information of Aurora A Inhibitor I, the solubility of Aurora A Inhibitor I in water, the solubility of Aurora A Inhibitor I in DMSO, the solubility of Aurora A Inhibitor I in PBS buffer, the animal experiment (test) of Aurora A Inhibitor I, the cell expriment (test) of Aurora A Inhibitor I, the in vivo, in vitro and clinical trial test of Aurora A Inhibitor I, the EC50, IC50,and affinity,of Aurora A Inhibitor I, Please contact DC Chemicals.
NSC 23766 supplier|NSC23766|DC Chemicals
NSC 23766 supplier|NSC23766|DC Chemicals
DC Chemicals provides NSC 23766, other names: NSC23766，NSC-23766, cas: 733767-34-5. In stock.
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NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
NSC 23766, other names: NSC23766，NSC-23766, cas: 733767-34-5, Molecule formular: C24H35N7, Molecule Weight: 421.58, Chemical name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification. NSC23766 effectively inhibits Rac1 binding and activation by the Rac-specific GEF Trio or Tiam1 in a dose-dependent manner without interfering with the closely related Cdc42 or RhoA binding or activation by their respective GEFs or with Rac1 interaction with BcrGAP or effector PAK1 [1]. 50 μM NSC 23766 inhibits thrombin-induced activation of Rac1 an d Rac2 in human platelets, as well as platelet aggregation [2]. NSC23766 regulates endothelial nitric oxide synthase expression and endothelial function. 100 μM NSC23766 represses the eNOS promoter activity by 60% in bovine aortic ECs and by 30% to 35% in bEND.3 cells. Inhibition of Rac1 with NSC23766 destabilizes eNOS mRNA and shortens its half-life to 17 hours. NSC23766 dose-dependently attenuates ACh-induced relaxation of wild-type mice aortic rings For the detailed information of NSC 23766, the solubility of NSC 23766 in water, the solubility of NSC 23766 in DMSO, the solubility of NSC 23766 in PBS buffer, the animal experiment (test) of NSC 23766, the cell expriment (test) of NSC 23766, the in vivo, in vitro and clinical trial test of NSC 23766, the EC50, IC50,and affinity,of NSC 23766, Please contact DC Chemicals.
DC Chemicals provides NSC 23766, other names: NSC23766，NSC-23766, cas: 733767-34-5. In stock.
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NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
NSC 23766, other names: NSC23766，NSC-23766, cas: 733767-34-5, Molecule formular: C24H35N7, Molecule Weight: 421.58, Chemical name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification. NSC23766 effectively inhibits Rac1 binding and activation by the Rac-specific GEF Trio or Tiam1 in a dose-dependent manner without interfering with the closely related Cdc42 or RhoA binding or activation by their respective GEFs or with Rac1 interaction with BcrGAP or effector PAK1 [1]. 50 μM NSC 23766 inhibits thrombin-induced activation of Rac1 an d Rac2 in human platelets, as well as platelet aggregation [2]. NSC23766 regulates endothelial nitric oxide synthase expression and endothelial function. 100 μM NSC23766 represses the eNOS promoter activity by 60% in bovine aortic ECs and by 30% to 35% in bEND.3 cells. Inhibition of Rac1 with NSC23766 destabilizes eNOS mRNA and shortens its half-life to 17 hours. NSC23766 dose-dependently attenuates ACh-induced relaxation of wild-type mice aortic rings For the detailed information of NSC 23766, the solubility of NSC 23766 in water, the solubility of NSC 23766 in DMSO, the solubility of NSC 23766 in PBS buffer, the animal experiment (test) of NSC 23766, the cell expriment (test) of NSC 23766, the in vivo, in vitro and clinical trial test of NSC 23766, the EC50, IC50,and affinity,of NSC 23766, Please contact DC Chemicals.
HPOB supplier|DC Chemicals
HPOB supplier|DC Chemicals
DC Chemicals provides HPOB, other names: , cas: 1429651-50-2. In stock.
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HPOB is a novel selective inhibitor of HDAC6 catalytic activity in vivo and in vitro.
HPOB, other names: , cas: 1429651-50-2, Molecule formular: C17H18N2O4, Molecule Weight: 314.34, Chemical name: N-Hydroxy-4-(2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl)benzamide
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).1 It is at least 30-fold less effective against other HDACs.1 Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.1 HPOB reduces the growth, but not the viability, of normal and transformed cells.1 It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.1 HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft. For the detailed information of HPOB, the solubility of HPOB in water, the solubility of HPOB in DMSO, the solubility of HPOB in PBS buffer, the animal experiment (test) of HPOB, the cell expriment (test) of HPOB, the in vivo, in vitro and clinical trial test of HPOB, the EC50, IC50,and affinity,of HPOB, Please contact DC Chemicals.
DC Chemicals provides HPOB, other names: , cas: 1429651-50-2. In stock.
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HPOB is a novel selective inhibitor of HDAC6 catalytic activity in vivo and in vitro.
HPOB, other names: , cas: 1429651-50-2, Molecule formular: C17H18N2O4, Molecule Weight: 314.34, Chemical name: N-Hydroxy-4-(2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl)benzamide
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).1 It is at least 30-fold less effective against other HDACs.1 Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.1 HPOB reduces the growth, but not the viability, of normal and transformed cells.1 It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.1 HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft. For the detailed information of HPOB, the solubility of HPOB in water, the solubility of HPOB in DMSO, the solubility of HPOB in PBS buffer, the animal experiment (test) of HPOB, the cell expriment (test) of HPOB, the in vivo, in vitro and clinical trial test of HPOB, the EC50, IC50,and affinity,of HPOB, Please contact DC Chemicals.
(-)MK-801 maleate supplier|MK 801 ，MK801 |DC Chemicals
(-)MK-801 maleate supplier|MK 801 ，MK801 |DC Chemicals
DC Chemicals provides (-)MK-801 maleate, other names: MK 801 ，MK801 , cas: 121917-57-5. In stock.
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(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .
(-)MK-801 maleate, other names: MK 801 ，MK801 , cas: 121917-57-5, Molecule formular: C20H19NO4, Molecule Weight: 337.37, Chemical name: (5R,10S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . For the detailed information of (-)MK-801 maleate, the solubility of (-)MK-801 maleate in water, the solubility of (-)MK-801 maleate in DMSO, the solubility of (-)MK-801 maleate in PBS buffer, the animal experiment (test) of (-)MK-801 maleate, the cell expriment (test) of (-)MK-801 maleate, the in vivo, in vitro and clinical trial test of (-)MK-801 maleate, the EC50, IC50,and affinity,of (-)MK-801 maleate, Please contact DC Chemicals.
DC Chemicals provides (-)MK-801 maleate, other names: MK 801 ，MK801 , cas: 121917-57-5. In stock.
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(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .
(-)MK-801 maleate, other names: MK 801 ，MK801 , cas: 121917-57-5, Molecule formular: C20H19NO4, Molecule Weight: 337.37, Chemical name: (5R,10S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . For the detailed information of (-)MK-801 maleate, the solubility of (-)MK-801 maleate in water, the solubility of (-)MK-801 maleate in DMSO, the solubility of (-)MK-801 maleate in PBS buffer, the animal experiment (test) of (-)MK-801 maleate, the cell expriment (test) of (-)MK-801 maleate, the in vivo, in vitro and clinical trial test of (-)MK-801 maleate, the EC50, IC50,and affinity,of (-)MK-801 maleate, Please contact DC Chemicals.
(+)MK-801 maleate supplier|MK801|DC Chemicals
(+)MK-801 maleate supplier|MK801|DC Chemicals
DC Chemicals provides (+)MK-801 maleate, other names: MK 801 ，MK801 , cas: 77086-22-7. In stock.
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Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM
(+)MK-801 maleate, other names: MK 801 ，MK801 , cas: 77086-22-7, Molecule formular: C20H19NO4, Molecule Weight: 337.37, Chemical name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of [3H] dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant[1]. The cytotoxicity of MK-801 on cultured microglia was also investigated. Cytotoxicity of MK-801 was reduced by the addition of L-glutamate, kainate and NMDA. The action of MK-801 was due to the direct action of microglia For the detailed information of (+)MK-801 maleate, the solubility of (+)MK-801 maleate in water, the solubility of (+)MK-801 maleate in DMSO, the solubility of (+)MK-801 maleate in PBS buffer, the animal experiment (test) of (+)MK-801 maleate, the cell expriment (test) of (+)MK-801 maleate, the in vivo, in vitro and clinical trial test of (+)MK-801 maleate, the EC50, IC50,and affinity,of (+)MK-801 maleate, Please contact DC Chemicals.
DC Chemicals provides (+)MK-801 maleate, other names: MK 801 ，MK801 , cas: 77086-22-7. In stock.
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Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM
(+)MK-801 maleate, other names: MK 801 ，MK801 , cas: 77086-22-7, Molecule formular: C20H19NO4, Molecule Weight: 337.37, Chemical name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of [3H] dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant[1]. The cytotoxicity of MK-801 on cultured microglia was also investigated. Cytotoxicity of MK-801 was reduced by the addition of L-glutamate, kainate and NMDA. The action of MK-801 was due to the direct action of microglia For the detailed information of (+)MK-801 maleate, the solubility of (+)MK-801 maleate in water, the solubility of (+)MK-801 maleate in DMSO, the solubility of (+)MK-801 maleate in PBS buffer, the animal experiment (test) of (+)MK-801 maleate, the cell expriment (test) of (+)MK-801 maleate, the in vivo, in vitro and clinical trial test of (+)MK-801 maleate, the EC50, IC50,and affinity,of (+)MK-801 maleate, Please contact DC Chemicals.
BMH-21 supplier|BMH21|DC Chemicals
BMH-21 supplier|BMH21|DC Chemicals
DC Chemicals provides BMH-21, other names: BMH 21，BMH21, cas: 896705-16-1. In stock.
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BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.
BMH-21, other names: BMH 21，BMH21, cas: 896705-16-1, Molecule formular: C21H20N4O2, Molecule Weight: 360.41, Chemical name: N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress For the detailed information of BMH-21, the solubility of BMH-21 in water, the solubility of BMH-21 in DMSO, the solubility of BMH-21 in PBS buffer, the animal experiment (test) of BMH-21, the cell expriment (test) of BMH-21, the in vivo, in vitro and clinical trial test of BMH-21, the EC50, IC50,and affinity,of BMH-21, Please contact DC Chemicals.
DC Chemicals provides BMH-21, other names: BMH 21，BMH21, cas: 896705-16-1. In stock.
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BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.
BMH-21, other names: BMH 21，BMH21, cas: 896705-16-1, Molecule formular: C21H20N4O2, Molecule Weight: 360.41, Chemical name: N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress For the detailed information of BMH-21, the solubility of BMH-21 in water, the solubility of BMH-21 in DMSO, the solubility of BMH-21 in PBS buffer, the animal experiment (test) of BMH-21, the cell expriment (test) of BMH-21, the in vivo, in vitro and clinical trial test of BMH-21, the EC50, IC50,and affinity,of BMH-21, Please contact DC Chemicals.
JNK-IN-8 supplier|JNKIN 8|DC Chemicals
JNK-IN-8 supplier|JNKIN 8|DC Chemicals
DC Chemicals provides JNK-IN-8, other names: JNKIN 8, cas: 1410880-22-6. In stock.
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JNK-IN-8 is a potent and irreversible JNK inhibitor that inhibits the phosphorylation of c-Jun.
JNK-IN-8, other names: JNKIN 8, cas: 1410880-22-6, Molecule formular: C₂₉H₂₉N₇O₂, Molecule Weight: 507.59, Chemical name: (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide
JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβ.JNK-IN-8 is a highly selective JNK inhibitor based on multiple profiling strategies. JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively. JNK-IN-8 inhibits c-Jun phosphorylation at submicromolar concentrations in cells. JNK-IN-8 will be broadly useful as a pharmacological probe of JNK-dependent signal transduction. For the detailed information of JNK-IN-8, the solubility of JNK-IN-8 in water, the solubility of JNK-IN-8 in DMSO, the solubility of JNK-IN-8 in PBS buffer, the animal experiment (test) of JNK-IN-8, the cell expriment (test) of JNK-IN-8, the in vivo, in vitro and clinical trial test of JNK-IN-8, the EC50, IC50,and affinity,of JNK-IN-8, Please contact DC Chemicals.
DC Chemicals provides JNK-IN-8, other names: JNKIN 8, cas: 1410880-22-6. In stock.
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JNK-IN-8 is a potent and irreversible JNK inhibitor that inhibits the phosphorylation of c-Jun.
JNK-IN-8, other names: JNKIN 8, cas: 1410880-22-6, Molecule formular: C₂₉H₂₉N₇O₂, Molecule Weight: 507.59, Chemical name: (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide
JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβ.JNK-IN-8 is a highly selective JNK inhibitor based on multiple profiling strategies. JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively. JNK-IN-8 inhibits c-Jun phosphorylation at submicromolar concentrations in cells. JNK-IN-8 will be broadly useful as a pharmacological probe of JNK-dependent signal transduction. For the detailed information of JNK-IN-8, the solubility of JNK-IN-8 in water, the solubility of JNK-IN-8 in DMSO, the solubility of JNK-IN-8 in PBS buffer, the animal experiment (test) of JNK-IN-8, the cell expriment (test) of JNK-IN-8, the in vivo, in vitro and clinical trial test of JNK-IN-8, the EC50, IC50,and affinity,of JNK-IN-8, Please contact DC Chemicals.
PF-06687859(RG-3039) supplier|DC Chemicals
PF-06687859(RG-3039) supplier|DC Chemicals
DC Chemicals provides PF-06687859/RG-3039 , other names: PF06687859，RG-3039 ，PF 06687859，RG 3039 , cas: 1005504-62-0 (RG3039 free base); 1466525-84-7 (RG3039·2HCl). In stock.
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RG3039 is a small molecule inhibitor of decapping enzyme scavenger (DCPS).
PF-06687859/RG-3039 , other names: PF06687859，RG-3039 ，PF 06687859，RG 3039 , cas: 1005504-62-0 (RG3039 free base); 1466525-84-7 (RG3039·2HCl), Molecule formular: C21H23Cl2N5O, Molecule Weight: 431.13, Chemical name: 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. (Last updated: 2/5/2015) For the detailed information of PF-06687859/RG-3039 , the solubility of PF-06687859/RG-3039 in water, the solubility of PF-06687859/RG-3039 in DMSO, the solubility of PF-06687859/RG-3039 in PBS buffer, the animal experiment (test) of PF-06687859/RG-3039 , the cell expriment (test) of PF-06687859/RG-3039 , the in vivo, in vitro and clinical trial test of PF-06687859/RG-3039 , the EC50, IC50,and affinity,of PF-06687859/RG-3039 , Please contact DC Chemicals.
DC Chemicals provides PF-06687859/RG-3039 , other names: PF06687859，RG-3039 ，PF 06687859，RG 3039 , cas: 1005504-62-0 (RG3039 free base); 1466525-84-7 (RG3039·2HCl). In stock.
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RG3039 is a small molecule inhibitor of decapping enzyme scavenger (DCPS).
PF-06687859/RG-3039 , other names: PF06687859，RG-3039 ，PF 06687859，RG 3039 , cas: 1005504-62-0 (RG3039 free base); 1466525-84-7 (RG3039·2HCl), Molecule formular: C21H23Cl2N5O, Molecule Weight: 431.13, Chemical name: 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. (Last updated: 2/5/2015) For the detailed information of PF-06687859/RG-3039 , the solubility of PF-06687859/RG-3039 in water, the solubility of PF-06687859/RG-3039 in DMSO, the solubility of PF-06687859/RG-3039 in PBS buffer, the animal experiment (test) of PF-06687859/RG-3039 , the cell expriment (test) of PF-06687859/RG-3039 , the in vivo, in vitro and clinical trial test of PF-06687859/RG-3039 , the EC50, IC50,and affinity,of PF-06687859/RG-3039 , Please contact DC Chemicals.
SP2509 supplier|SP-2509|DC Chemicals
SP2509 supplier|SP-2509|DC Chemicals
DC Chemicals provides SP2509, other names: SP 2509，SP-2509, cas: 1423715-09-6. In stock.
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SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B.
SP2509, other names: SP 2509，SP-2509, cas: 1423715-09-6, Molecule formular: C19H20ClN3O5S, Molecule Weight: 437.9, Chemical name: (E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide.
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. (Last updated: 2/5/2015) For the detailed information of PF-06687859/RG-3039 , the solubility of PF-06687859/RG-3039 in water, the solubility of PF-06687859/RG-3039 in DMSO, the solubility of PF-06687859/RG-3039 in PBS buffer, the animal experiment (test) of PF-06687859/RG-3039 , the cell expriment (test) of PF-06687859/RG-3039 , the in vivo, in vitro and clinical trial test of PF-06687859/RG-3039 , the EC50, IC50,and affinity,of PF-06687859/RG-3039 , Please contact DC Chemicals.
DC Chemicals provides SP2509, other names: SP 2509，SP-2509, cas: 1423715-09-6. In stock.
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SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B.
SP2509, other names: SP 2509，SP-2509, cas: 1423715-09-6, Molecule formular: C19H20ClN3O5S, Molecule Weight: 437.9, Chemical name: (E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide.
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. (Last updated: 2/5/2015) For the detailed information of PF-06687859/RG-3039 , the solubility of PF-06687859/RG-3039 in water, the solubility of PF-06687859/RG-3039 in DMSO, the solubility of PF-06687859/RG-3039 in PBS buffer, the animal experiment (test) of PF-06687859/RG-3039 , the cell expriment (test) of PF-06687859/RG-3039 , the in vivo, in vitro and clinical trial test of PF-06687859/RG-3039 , the EC50, IC50,and affinity,of PF-06687859/RG-3039 , Please contact DC Chemicals.
BRL 52537 HYDROCHLORIDE supplier|BRL52537|DC Chemicals
BRL 52537 HYDROCHLORIDE supplier|BRL52537|DC Chemicals
DC Chemicals provides BRL 52537 HYDROCHLORIDE, other names: BRL-52537，BRL52537 , cas: 130497-33-5. In stock.
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BRL 52537 hydrochloride is a potent and highly selective KOR-1 ( κ-opioid receptor) and MOR (μ-opioid receptor) agonist.
BRL 52537 HYDROCHLORIDE, other names: BRL-52537，BRL52537 , cas: 130497-33-5, Molecule formular: C18H24Cl2N2O.ClH, Molecule Weight: 391.77, Chemical name: (±)-1-(3,4-Dichlorophenyl)acetyl-2-( 1-pyrrolidinyl)methylpiperidine hydrochloride - See more at: http://www.activebiopharma.com/130497-33-5#sthash.eEH2hqW0.dpuf
BRL 52537 hydrochloride is a potent and highly selective KOR-1 ( κ-opioid receptor) and MOR (μ-opioid receptor) agonist [25 times more potent than morphine]. For the detailed information of BRL 52537 HYDROCHLORIDE, the solubility of BRL 52537 HYDROCHLORIDE in water, the solubility of BRL 52537 HYDROCHLORIDE in DMSO, the solubility of BRL 52537 HYDROCHLORIDE in PBS buffer, the animal experiment (test) of BRL 52537 HYDROCHLORIDE, the cell expriment (test) of BRL 52537 HYDROCHLORIDE, the in vivo, in vitro and clinical trial test of BRL 52537 HYDROCHLORIDE, the EC50, IC50,and affinity,of BRL 52537 HYDROCHLORIDE, Please contact DC Chemicals.
DC Chemicals provides BRL 52537 HYDROCHLORIDE, other names: BRL-52537，BRL52537 , cas: 130497-33-5. In stock.
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BRL 52537 hydrochloride is a potent and highly selective KOR-1 ( κ-opioid receptor) and MOR (μ-opioid receptor) agonist.
BRL 52537 HYDROCHLORIDE, other names: BRL-52537，BRL52537 , cas: 130497-33-5, Molecule formular: C18H24Cl2N2O.ClH, Molecule Weight: 391.77, Chemical name: (±)-1-(3,4-Dichlorophenyl)acetyl-2-( 1-pyrrolidinyl)methylpiperidine hydrochloride - See more at: http://www.activebiopharma.com/130497-33-5#sthash.eEH2hqW0.dpuf
BRL 52537 hydrochloride is a potent and highly selective KOR-1 ( κ-opioid receptor) and MOR (μ-opioid receptor) agonist [25 times more potent than morphine]. For the detailed information of BRL 52537 HYDROCHLORIDE, the solubility of BRL 52537 HYDROCHLORIDE in water, the solubility of BRL 52537 HYDROCHLORIDE in DMSO, the solubility of BRL 52537 HYDROCHLORIDE in PBS buffer, the animal experiment (test) of BRL 52537 HYDROCHLORIDE, the cell expriment (test) of BRL 52537 HYDROCHLORIDE, the in vivo, in vitro and clinical trial test of BRL 52537 HYDROCHLORIDE, the EC50, IC50,and affinity,of BRL 52537 HYDROCHLORIDE, Please contact DC Chemicals.
GR 127935 HCL supplier|GR127935 |DC Chemicals
GR 127935 HCL supplier|GR127935 |DC Chemicals
DC Chemicals provides GR 127935 HCL, other names: GR-127935 ，GR127935 , cas: 148672-13-3. In stock.
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GR 127935 HCL is a putative and selective 5-HT1B/1D antagonist.
GR 127935 HCL, other names: GR-127935 ，GR127935 , cas: 148672-13-3, Molecule formular: C29H31N5O3, Molecule Weight: 497.59, Chemical name: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide
Putative and selective 5-HT1B/1D antagonist For the detailed information of GR 127935 HCL, the solubility of GR 127935 HCL in water, the solubility of GR 127935 HCL in DMSO, the solubility of GR 127935 HCL in PBS buffer, the animal experiment (test) of GR 127935 HCL, the cell expriment (test) of GR 127935 HCL, the in vivo, in vitro and clinical trial test of GR 127935 HCL, the EC50, IC50,and affinity,of GR 127935 HCL, Please contact DC Chemicals.
DC Chemicals provides GR 127935 HCL, other names: GR-127935 ，GR127935 , cas: 148672-13-3. In stock.
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GR 127935 HCL is a putative and selective 5-HT1B/1D antagonist.
GR 127935 HCL, other names: GR-127935 ，GR127935 , cas: 148672-13-3, Molecule formular: C29H31N5O3, Molecule Weight: 497.59, Chemical name: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide
Putative and selective 5-HT1B/1D antagonist For the detailed information of GR 127935 HCL, the solubility of GR 127935 HCL in water, the solubility of GR 127935 HCL in DMSO, the solubility of GR 127935 HCL in PBS buffer, the animal experiment (test) of GR 127935 HCL, the cell expriment (test) of GR 127935 HCL, the in vivo, in vitro and clinical trial test of GR 127935 HCL, the EC50, IC50,and affinity,of GR 127935 HCL, Please contact DC Chemicals.
GNE-493 supplier|GNE493|DC Chemicals
GNE-493 supplier|GNE493|DC Chemicals
DC Chemicals provides GNE-493, other names: GNE 493，GNE493, cas: 1033735-94-2. In stock.
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GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively.
GNE-493, other names: GNE 493，GNE493, cas: 1033735-94-2, Molecule formular: C17H20N6O2S, Molecule Weight: 372.44, Chemical name: 2-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol
GNE-493 has good pharmacokinetic (PK) parameters, GNE-493 is highly selective, demonstrate knock down of pathway markers in vivo, and are efficacious in xenograft models where the PI3K pathway is deregulated. GNE-493 was compared in a PI3KR mutated MCF7.1 xenograft model and were found to have equivalent efficacy when normalized for exposure. For the detailed information of GNE-493, the solubility of GNE-493 in water, the solubility of GNE-493 in DMSO, the solubility of GNE-493 in PBS buffer, the animal experiment (test) of GNE-493, the cell expriment (test) of GNE-493, the in vivo, in vitro and clinical trial test of GNE-493, the EC50, IC50,and affinity,of GNE-493, Please contact DC Chemicals.
DC Chemicals provides GNE-493, other names: GNE 493，GNE493, cas: 1033735-94-2. In stock.
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GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively.
GNE-493, other names: GNE 493，GNE493, cas: 1033735-94-2, Molecule formular: C17H20N6O2S, Molecule Weight: 372.44, Chemical name: 2-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol
GNE-493 has good pharmacokinetic (PK) parameters, GNE-493 is highly selective, demonstrate knock down of pathway markers in vivo, and are efficacious in xenograft models where the PI3K pathway is deregulated. GNE-493 was compared in a PI3KR mutated MCF7.1 xenograft model and were found to have equivalent efficacy when normalized for exposure. For the detailed information of GNE-493, the solubility of GNE-493 in water, the solubility of GNE-493 in DMSO, the solubility of GNE-493 in PBS buffer, the animal experiment (test) of GNE-493, the cell expriment (test) of GNE-493, the in vivo, in vitro and clinical trial test of GNE-493, the EC50, IC50,and affinity,of GNE-493, Please contact DC Chemicals.
capasazepine supplier||DC Chemicals
capasazepine supplier||DC Chemicals
DC Chemicals provides capasazepine , other names: , cas: 138977-28-3. In stock.
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Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin; potent TRPV1 receptor antagonist with IC50 of 562 nM.
capasazepine , other names: , cas: 138977-28-3, Molecule formular: C19H21ClN2O2S, Molecule Weight: 376.9, Chemical name: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
Capsazepine potentiated the effect of TRAIL, as shown by its effect on intracellular esterase activity; activation of caspase-8,-9, and -3; and colony-formation assay. Capsazepine induced death receptors (DRs) DR5 and DR4, but not decoy receptors, at the transcriptional level and in a non-cell-type-specific manner [2]. Capsazepine (10 microM) reversibly reduced or abolished the current response to capsaicin (500 nM) of voltage-clamped dorsal root ganglion (DRG) neurones from rats For the detailed information of capasazepine , the solubility of capasazepine in water, the solubility of capasazepine in DMSO, the solubility of capasazepine in PBS buffer, the animal experiment (test) of capasazepine , the cell expriment (test) of capasazepine , the in vivo, in vitro and clinical trial test of capasazepine , the EC50, IC50,and affinity,of capasazepine , Please contact DC Chemicals.
DC Chemicals provides capasazepine , other names: , cas: 138977-28-3. In stock.
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Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin; potent TRPV1 receptor antagonist with IC50 of 562 nM.
capasazepine , other names: , cas: 138977-28-3, Molecule formular: C19H21ClN2O2S, Molecule Weight: 376.9, Chemical name: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
Capsazepine potentiated the effect of TRAIL, as shown by its effect on intracellular esterase activity; activation of caspase-8,-9, and -3; and colony-formation assay. Capsazepine induced death receptors (DRs) DR5 and DR4, but not decoy receptors, at the transcriptional level and in a non-cell-type-specific manner [2]. Capsazepine (10 microM) reversibly reduced or abolished the current response to capsaicin (500 nM) of voltage-clamped dorsal root ganglion (DRG) neurones from rats For the detailed information of capasazepine , the solubility of capasazepine in water, the solubility of capasazepine in DMSO, the solubility of capasazepine in PBS buffer, the animal experiment (test) of capasazepine , the cell expriment (test) of capasazepine , the in vivo, in vitro and clinical trial test of capasazepine , the EC50, IC50,and affinity,of capasazepine , Please contact DC Chemicals.
Glutaminase Inhibitor II, BPTES supplier||DC Chemicals
Glutaminase Inhibitor II, BPTES supplier||DC Chemicals
DC Chemicals provides Glutaminase Inhibitor II, BPTES, other names: , cas: 314045-39-1. In stock.
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BPTES is a selective inhibitor of Glutaminase GLS1 (KGA)
Glutaminase Inhibitor II, BPTES, other names: , cas: 314045-39-1, Molecule formular: C24H24N6O2S3
, Molecule Weight: 524.68, Chemical name: Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide
BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. Glutaminase converts glutamine to glutamate, which is an important excitatory neurotransmitter in brain and can be further oxidized to α-ketoglutarate to feed the tricarboxylic acid (TCA) cycle and to glutathione, which is important for controlling the level of reactive oxygen species (ROS), particularly important for cancer cell growth. BPTES was found to slow growth of glioma cells. BPTES is a noncompetitive inhibitor with a Ki of 3 μM. For the detailed information of Glutaminase Inhibitor II, BPTES, the solubility of Glutaminase Inhibitor II, BPTES in water, the solubility of Glutaminase Inhibitor II, BPTES in DMSO, the solubility of Glutaminase Inhibitor II, BPTES in PBS buffer, the animal experiment (test) of Glutaminase Inhibitor II, BPTES, the cell expriment (test) of Glutaminase Inhibitor II, BPTES, the in vivo, in vitro and clinical trial test of Glutaminase Inhibitor II, BPTES, the EC50, IC50,and affinity,of Glutaminase Inhibitor II, BPTES, Please contact DC Chemicals.
DC Chemicals provides Glutaminase Inhibitor II, BPTES, other names: , cas: 314045-39-1. In stock.
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BPTES is a selective inhibitor of Glutaminase GLS1 (KGA)
Glutaminase Inhibitor II, BPTES, other names: , cas: 314045-39-1, Molecule formular: C24H24N6O2S3
, Molecule Weight: 524.68, Chemical name: Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide
BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. Glutaminase converts glutamine to glutamate, which is an important excitatory neurotransmitter in brain and can be further oxidized to α-ketoglutarate to feed the tricarboxylic acid (TCA) cycle and to glutathione, which is important for controlling the level of reactive oxygen species (ROS), particularly important for cancer cell growth. BPTES was found to slow growth of glioma cells. BPTES is a noncompetitive inhibitor with a Ki of 3 μM. For the detailed information of Glutaminase Inhibitor II, BPTES, the solubility of Glutaminase Inhibitor II, BPTES in water, the solubility of Glutaminase Inhibitor II, BPTES in DMSO, the solubility of Glutaminase Inhibitor II, BPTES in PBS buffer, the animal experiment (test) of Glutaminase Inhibitor II, BPTES, the cell expriment (test) of Glutaminase Inhibitor II, BPTES, the in vivo, in vitro and clinical trial test of Glutaminase Inhibitor II, BPTES, the EC50, IC50,and affinity,of Glutaminase Inhibitor II, BPTES, Please contact DC Chemicals.
UMI-77 supplier|UMI77|DC Chemicals
UMI-77 supplier|UMI77|DC Chemicals
DC Chemicals provides UMI-77, other names: UMI 77，UMI77, cas: 518303-20-3. In stock.
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UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
UMI-77, other names: UMI 77，UMI77, cas: 518303-20-3, Molecule formular: C18H14BrNO5S2, Molecule Weight: 468.34, Chemical name: 2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid
UMI-77 effectively disrupts the interactions between BL-Noxa and cellular Mcl-1, as well as Mcl-1/Bax protein–protein interactions. [1] UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induced apoptosis in pancreatic cancer through activation of the intrinsic apoptotic pathway and/or Bax conformational change. For the detailed information of UMI-77, the solubility of UMI-77 in water, the solubility of UMI-77 in DMSO, the solubility of UMI-77 in PBS buffer, the animal experiment (test) of UMI-77, the cell expriment (test) of UMI-77, the in vivo, in vitro and clinical trial test of UMI-77, the EC50, IC50,and affinity,of UMI-77, Please contact DC Chemicals.
DC Chemicals provides UMI-77, other names: UMI 77，UMI77, cas: 518303-20-3. In stock.
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Tel: +86-21-58447131;Fax:+86-21-61643280；
UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
UMI-77, other names: UMI 77，UMI77, cas: 518303-20-3, Molecule formular: C18H14BrNO5S2, Molecule Weight: 468.34, Chemical name: 2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid
UMI-77 effectively disrupts the interactions between BL-Noxa and cellular Mcl-1, as well as Mcl-1/Bax protein–protein interactions. [1] UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induced apoptosis in pancreatic cancer through activation of the intrinsic apoptotic pathway and/or Bax conformational change. For the detailed information of UMI-77, the solubility of UMI-77 in water, the solubility of UMI-77 in DMSO, the solubility of UMI-77 in PBS buffer, the animal experiment (test) of UMI-77, the cell expriment (test) of UMI-77, the in vivo, in vitro and clinical trial test of UMI-77, the EC50, IC50,and affinity,of UMI-77, Please contact DC Chemicals.
Picoxystrobin supplier||DC Chemicals
Picoxystrobin supplier||DC Chemicals
DC Chemicals provides Picoxystrobin, other names: , cas: 117428-22-5. In stock.
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Picoxystrobin is an methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases.
Picoxystrobin, other names: , cas: 117428-22-5, Molecule formular: C18H16F3NO4
, Molecule Weight: 367.32, Chemical name: methyl (2Z)-3-methoxy-2-[2-({[6-(trifluoromethyl)pyridin-2-yl]oxy}methyl)phenyl]prop-2-enoate
For the detailed information of Picoxystrobin, the solubility of Picoxystrobin in water, the solubility of Picoxystrobin in DMSO, the solubility of Picoxystrobin in PBS buffer, the animal experiment (test) of Picoxystrobin, the cell expriment (test) of Picoxystrobin, the in vivo, in vitro and clinical trial test of Picoxystrobin, the EC50, IC50,and affinity,of Picoxystrobin, Please contact DC Chemicals.
DC Chemicals provides Picoxystrobin, other names: , cas: 117428-22-5. In stock.
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Picoxystrobin is an methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases.
Picoxystrobin, other names: , cas: 117428-22-5, Molecule formular: C18H16F3NO4
, Molecule Weight: 367.32, Chemical name: methyl (2Z)-3-methoxy-2-[2-({[6-(trifluoromethyl)pyridin-2-yl]oxy}methyl)phenyl]prop-2-enoate
For the detailed information of Picoxystrobin, the solubility of Picoxystrobin in water, the solubility of Picoxystrobin in DMSO, the solubility of Picoxystrobin in PBS buffer, the animal experiment (test) of Picoxystrobin, the cell expriment (test) of Picoxystrobin, the in vivo, in vitro and clinical trial test of Picoxystrobin, the EC50, IC50,and affinity,of Picoxystrobin, Please contact DC Chemicals.
PRT-060318 supplier|PRT060318 |DC Chemicals
PRT-060318 supplier|PRT060318 |DC Chemicals
DC Chemicals provides PRT-060318 , other names: PRT 060318 ，PRT060318 , cas: 1194961-19-7. In stock.
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PRT-060318 is a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in
a transgenic mouse model.
DC Chemicals provides PRT-060318 , other names: PRT 060318 ，PRT060318 , cas: 1194961-19-7. In stock.
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PRT-060318 is a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in
a transgenic mouse model.
PRT-060318 , other names: PRT 060318 ，PRT060318 , cas: 1194961-19-7, Molecule formular: C18H24N6O, Molecule Weight: 340.4, Chemical name: 2-(((1R,2S)-2-aminocyclohexyl)amino)-4-
(m-tolylamino)pyrimidine-5-carboxamide
PRT-060318, also known as PRT318 or P142–76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. (source: Blood. 2011 Feb 17;117(7):2241-6.) For the detailed information of PRT-060318 , the solubility of PRT-060318 in water, the solubility of PRT-060318 in DMSO, the solubility of PRT-060318 in PBS buffer, the animal experiment (test) of PRT-060318 , the cell expriment (test) of PRT-060318 , the in vivo, in vitro and clinical trial test of PRT-060318 , the EC50, IC50,and affinity,of PRT-060318 , Please contact DC Chemicals.
Ledipasvir supplier|GS 5885|DC Chemicals
Ledipasvir supplier|GS 5885|DC Chemicals
DC Chemicals provides Ledipasvir, other names: GS 5885，GS-5885，GS5885, cas: 1256388-51-8. In stock.
Contact: website: www.dcchemicals.com,
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Tel: +86-21-58447131;Fax:+86-21-61643277；
Ledipasvir(GS5885) is an inhibitor of the hepatitis C virus NS5A protein. Ledipasvir is an experimental drug for the treatment of hepatitis C.
Ledipasvir, other names: GS 5885，GS-5885，GS5885, cas: 1256388-51-8, Molecule formular: C49H54F2N8O6, Molecule Weight: 889, Chemical name:
GS-5885 was well tolerated and resulted in median maximal reductions in HCV RNA ranging from 2.3 log(10) IU/ml (1 mg QD) to 3.3 log(10) IU/ml (10 mg QD in genotype 1b and 30 mg QD). E(max) modeling indicated GS-5885 30 mg was associated with>95% of maximal antiviral response to HCV genotype 1a. HCV RNA reductions were generally more sustained among patients with genotype 1b vs. 1a. Three of 60 patients had a reduced response and harbored NS5A-resistant virus at baseline. NS5A sequencing identified residues 30 and 31 in genotype 1a, and 93 in genotype 1b as the predominant sites of mutation following GS-5885 dosing. Plasma pharmacokinetics was consistent with QD dosing For the detailed information of Ledipasvir, the solubility of Ledipasvir in water, the solubility of Ledipasvir in DMSO, the solubility of Ledipasvir in PBS buffer, the animal experiment (test) of Ledipasvir, the cell expriment (test) of Ledipasvir, the in vivo, in vitro and clinical trial test of Ledipasvir, the EC50, IC50,and affinity,of Ledipasvir, Please contact DC Chemicals.
DC Chemicals provides Ledipasvir, other names: GS 5885，GS-5885，GS5885, cas: 1256388-51-8. In stock.
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Ledipasvir(GS5885) is an inhibitor of the hepatitis C virus NS5A protein. Ledipasvir is an experimental drug for the treatment of hepatitis C.
Ledipasvir, other names: GS 5885，GS-5885，GS5885, cas: 1256388-51-8, Molecule formular: C49H54F2N8O6, Molecule Weight: 889, Chemical name:
GS-5885 was well tolerated and resulted in median maximal reductions in HCV RNA ranging from 2.3 log(10) IU/ml (1 mg QD) to 3.3 log(10) IU/ml (10 mg QD in genotype 1b and 30 mg QD). E(max) modeling indicated GS-5885 30 mg was associated with>95% of maximal antiviral response to HCV genotype 1a. HCV RNA reductions were generally more sustained among patients with genotype 1b vs. 1a. Three of 60 patients had a reduced response and harbored NS5A-resistant virus at baseline. NS5A sequencing identified residues 30 and 31 in genotype 1a, and 93 in genotype 1b as the predominant sites of mutation following GS-5885 dosing. Plasma pharmacokinetics was consistent with QD dosing For the detailed information of Ledipasvir, the solubility of Ledipasvir in water, the solubility of Ledipasvir in DMSO, the solubility of Ledipasvir in PBS buffer, the animal experiment (test) of Ledipasvir, the cell expriment (test) of Ledipasvir, the in vivo, in vitro and clinical trial test of Ledipasvir, the EC50, IC50,and affinity,of Ledipasvir, Please contact DC Chemicals.
SKF-86002 supplier|SKF86002|DC Chemicals
SKF-86002 supplier|SKF86002|DC Chemicals
DC Chemicals provides SKF-86002, other names: SKF 86002，SKF86002, cas: 72873-74-6. In stock.
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SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
SKF-86002, other names: SKF 86002，SKF86002, cas: 72873-74-6, Molecule formular: C16H12FN3S, Molecule Weight: 297.35, Chemical name: 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP For the detailed information of SKF-86002, the solubility of SKF-86002 in water, the solubility of SKF-86002 in DMSO, the solubility of SKF-86002 in PBS buffer, the animal experiment (test) of SKF-86002, the cell expriment (test) of SKF-86002, the in vivo, in vitro and clinical trial test of SKF-86002, the EC50, IC50,and affinity,of SKF-86002, Please contact DC Chemicals.
DC Chemicals provides SKF-86002, other names: SKF 86002，SKF86002, cas: 72873-74-6. In stock.
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SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
SKF-86002, other names: SKF 86002，SKF86002, cas: 72873-74-6, Molecule formular: C16H12FN3S, Molecule Weight: 297.35, Chemical name: 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP For the detailed information of SKF-86002, the solubility of SKF-86002 in water, the solubility of SKF-86002 in DMSO, the solubility of SKF-86002 in PBS buffer, the animal experiment (test) of SKF-86002, the cell expriment (test) of SKF-86002, the in vivo, in vitro and clinical trial test of SKF-86002, the EC50, IC50,and affinity,of SKF-86002, Please contact DC Chemicals.
TAK-063 supplier|TAK063|DC Chemicals
TAK-063 supplier|TAK063|DC Chemicals
DC Chemicals provides TAK-063, other names: TAK 063，TAK063, cas: 1238697-26-1. In stock.
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TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
TAK-063, other names: TAK 063，TAK063, cas: 1238697-26-1, Molecule formular: C23H17FN6O2, Molecule Weight: 428.42, Chemical name: 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
TAK-063 has potent inhibitory activity (IC50 = 0.30 nM), excellent selectivity (>15000-fold selectivity over other PDEs), and favorable pharmacokinetics, including high brain penetration, in mice. Oral administration of TAK-063 to mice elevated striatal 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) levels at 0.3 mg/kg and showed potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg [1]. TAK-063 at 0.3 and 1 mg/kg, p.o., increased cAMP and cGMP levels in the rodent striatum and upregulated phosphorylation levels of key substrates of cAMP-dependent and cGMP-dependent protein kinases. TAK-063 at 0.3 and 1 mg/kg, p.o., strongly suppressed MK-801-induced hyperlocomotion that is often used as a predictive model for antipsychotic-like activity in rodents. TAK-063 did not affect plasma prolactin or glucose levels at doses up to 3 mg/kg, p.o. TAK-063 at 3 mg/kg, p.o., elicited a weak cataleptic response compared with haloperidol and olanzapine For the detailed information of TAK-063, the solubility of TAK-063 in water, the solubility of TAK-063 in DMSO, the solubility of TAK-063 in PBS buffer, the animal experiment (test) of TAK-063, the cell expriment (test) of TAK-063, the in vivo, in vitro and clinical trial test of TAK-063, the EC50, IC50,and affinity,of TAK-063, Please contact DC Chemicals.
DC Chemicals provides TAK-063, other names: TAK 063，TAK063, cas: 1238697-26-1. In stock.
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TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
TAK-063, other names: TAK 063，TAK063, cas: 1238697-26-1, Molecule formular: C23H17FN6O2, Molecule Weight: 428.42, Chemical name: 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
TAK-063 has potent inhibitory activity (IC50 = 0.30 nM), excellent selectivity (>15000-fold selectivity over other PDEs), and favorable pharmacokinetics, including high brain penetration, in mice. Oral administration of TAK-063 to mice elevated striatal 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) levels at 0.3 mg/kg and showed potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg [1]. TAK-063 at 0.3 and 1 mg/kg, p.o., increased cAMP and cGMP levels in the rodent striatum and upregulated phosphorylation levels of key substrates of cAMP-dependent and cGMP-dependent protein kinases. TAK-063 at 0.3 and 1 mg/kg, p.o., strongly suppressed MK-801-induced hyperlocomotion that is often used as a predictive model for antipsychotic-like activity in rodents. TAK-063 did not affect plasma prolactin or glucose levels at doses up to 3 mg/kg, p.o. TAK-063 at 3 mg/kg, p.o., elicited a weak cataleptic response compared with haloperidol and olanzapine For the detailed information of TAK-063, the solubility of TAK-063 in water, the solubility of TAK-063 in DMSO, the solubility of TAK-063 in PBS buffer, the animal experiment (test) of TAK-063, the cell expriment (test) of TAK-063, the in vivo, in vitro and clinical trial test of TAK-063, the EC50, IC50,and affinity,of TAK-063, Please contact DC Chemicals.
LY2090314 supplier|LY-2090314|DC Chemicals
LY2090314 supplier|LY-2090314|DC Chemicals
DC Chemicals provides LY2090314, other names: LY 2090314，LY-2090314, cas: 603288-22-8. In stock.
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LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
LY2090314, other names: LY 2090314，LY-2090314, cas: 603288-22-8, Molecule formular: C28H25FN6O3, Molecule Weight: 512.53, Chemical name: 3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.
in vivo: Even in Mdr1a-, Bcrp-, and Mrp2-knockout rats, LY2090314 metabolites did not appear in circulation, and their urinary excretion was not enhanced, because the hypothesized impaired biliary excretion of metabolites in the absence of these canalicular transporters was not observed. Canine metabolite disposition was generally similar, with the notable exception of dog-unique LY2090314 glucuronide For the detailed information of LY2090314, the solubility of LY2090314 in water, the solubility of LY2090314 in DMSO, the solubility of LY2090314 in PBS buffer, the animal experiment (test) of LY2090314, the cell expriment (test) of LY2090314, the in vivo, in vitro and clinical trial test of LY2090314, the EC50, IC50,and affinity,of LY2090314, Please contact DC Chemicals.
DC Chemicals provides LY2090314, other names: LY 2090314，LY-2090314, cas: 603288-22-8. In stock.
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LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.
LY2090314, other names: LY 2090314，LY-2090314, cas: 603288-22-8, Molecule formular: C28H25FN6O3, Molecule Weight: 512.53, Chemical name: 3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro.
in vivo: Even in Mdr1a-, Bcrp-, and Mrp2-knockout rats, LY2090314 metabolites did not appear in circulation, and their urinary excretion was not enhanced, because the hypothesized impaired biliary excretion of metabolites in the absence of these canalicular transporters was not observed. Canine metabolite disposition was generally similar, with the notable exception of dog-unique LY2090314 glucuronide For the detailed information of LY2090314, the solubility of LY2090314 in water, the solubility of LY2090314 in DMSO, the solubility of LY2090314 in PBS buffer, the animal experiment (test) of LY2090314, the cell expriment (test) of LY2090314, the in vivo, in vitro and clinical trial test of LY2090314, the EC50, IC50,and affinity,of LY2090314, Please contact DC Chemicals.
LY2584702 supplier|LY-2584702|DC Chemicals
LY2584702 supplier|LY-2584702|DC Chemicals
DC Chemicals provides LY2584702, other names: LY-2584702，LY 2584702, cas: 1082949-67-4. In stock.
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LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.
LY2584702, other names: LY-2584702，LY 2584702, cas: 1082949-67-4, Molecule formular: C21H19F4N7, Molecule Weight: 445.42, Chemical name: 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine
LY-2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival. For the detailed information of LY2584702, the solubility of LY2584702 in water, the solubility of LY2584702 in DMSO, the solubility of LY2584702 in PBS buffer, the animal experiment (test) of LY2584702, the cell expriment (test) of LY2584702, the in vivo, in vitro and clinical trial test of LY2584702, the EC50, IC50,and affinity,of LY2584702, Please contact DC Chemicals.
DC Chemicals provides LY2584702, other names: LY-2584702，LY 2584702, cas: 1082949-67-4. In stock.
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LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.
LY2584702, other names: LY-2584702，LY 2584702, cas: 1082949-67-4, Molecule formular: C21H19F4N7, Molecule Weight: 445.42, Chemical name: 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine
LY-2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival. For the detailed information of LY2584702, the solubility of LY2584702 in water, the solubility of LY2584702 in DMSO, the solubility of LY2584702 in PBS buffer, the animal experiment (test) of LY2584702, the cell expriment (test) of LY2584702, the in vivo, in vitro and clinical trial test of LY2584702, the EC50, IC50,and affinity,of LY2584702, Please contact DC Chemicals.
ML-265 supplier|ML265|DC Chemicals
ML-265 supplier|ML265|DC Chemicals
DC Chemicals provides ML-265, other names: ML 265，ML265, cas: 1221186-53-3. In stock.
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ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization.
ML-265, other names: ML 265，ML265, cas: 1221186-53-3, Molecule formular: C17H16N4O2S2, Molecule Weight: 372.5, Chemical name: 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2’,3’:4,5]pyrrolo[2,3-d]pyridazin-5-one
Pyruvate kinase catalyzes the final step in glycolysis, the formation of pyruvate and ATP from phosphoenolpyruvate and ADP. The expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in the metabolic reprogramming of tumor cells, which require high amounts of glucose for proliferation. PKM2 is allosterically regulated by the upstream glycolytic intermediate, fructose-1,6-bisphosphate (FBP), which controls glycolysis in a feed forward mechanism.1 Whereas cancer cells exist in highly phosphorylated states, the binding of certain peptide motifs with phosphorylated tyrosines can inhibit PKM2 activity by causing the release of FBP from the allosteric site.1 ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme.2 It demonstrates >100-fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms.2 At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma. For the detailed information of ML-265, the solubility of ML-265 in water, the solubility of ML-265 in DMSO, the solubility of ML-265 in PBS buffer, the animal experiment (test) of ML-265, the cell expriment (test) of ML-265, the in vivo, in vitro and clinical trial test of ML-265, the EC50, IC50,and affinity,of ML-265, Please contact DC Chemicals.
DC Chemicals provides ML-265, other names: ML 265，ML265, cas: 1221186-53-3. In stock.
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ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization.
ML-265, other names: ML 265，ML265, cas: 1221186-53-3, Molecule formular: C17H16N4O2S2, Molecule Weight: 372.5, Chemical name: 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2’,3’:4,5]pyrrolo[2,3-d]pyridazin-5-one
Pyruvate kinase catalyzes the final step in glycolysis, the formation of pyruvate and ATP from phosphoenolpyruvate and ADP. The expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in the metabolic reprogramming of tumor cells, which require high amounts of glucose for proliferation. PKM2 is allosterically regulated by the upstream glycolytic intermediate, fructose-1,6-bisphosphate (FBP), which controls glycolysis in a feed forward mechanism.1 Whereas cancer cells exist in highly phosphorylated states, the binding of certain peptide motifs with phosphorylated tyrosines can inhibit PKM2 activity by causing the release of FBP from the allosteric site.1 ML-265 activates tumor-specific PKM2 (EC50 = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing tetramerization, which is the most active form of the enzyme.2 It demonstrates >100-fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms.2 At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma. For the detailed information of ML-265, the solubility of ML-265 in water, the solubility of ML-265 in DMSO, the solubility of ML-265 in PBS buffer, the animal experiment (test) of ML-265, the cell expriment (test) of ML-265, the in vivo, in vitro and clinical trial test of ML-265, the EC50, IC50,and affinity,of ML-265, Please contact DC Chemicals.
PF-431396 supplier|PF431396|DC Chemicals
PF-431396 supplier|PF431396|DC Chemicals
DC Chemicals provides PF-431396, other names: PF 431396，PF431396, cas: 717906-29-1. In stock.
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PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor , PF-431396 has a Kd value of 445 nM for BRD4.
PF-431396, other names: PF 431396，PF431396, cas: 717906-29-1, Molecule formular: C22H21F3N6O3S, Molecule Weight: 506.5, Chemical name: N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells with PF-431396 blocked anti-Ig-induced tyrosine phosphorylation of Pyk2 and FAK when the cells were stimulated in suspension when they were stimulated on ECM [3]. Nanomolar affinities were also determined for PF-431396 (Kd = 445 ± 42 nM) and for the PIM inhibitor (Kd = 565 ± 63 nM) For the detailed information of PF-431396, the solubility of PF-431396 in water, the solubility of PF-431396 in DMSO, the solubility of PF-431396 in PBS buffer, the animal experiment (test) of PF-431396, the cell expriment (test) of PF-431396, the in vivo, in vitro and clinical trial test of PF-431396, the EC50, IC50,and affinity,of PF-431396, Please contact DC Chemicals.
DC Chemicals provides PF-431396, other names: PF 431396，PF431396, cas: 717906-29-1. In stock.
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PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor , PF-431396 has a Kd value of 445 nM for BRD4.
PF-431396, other names: PF 431396，PF431396, cas: 717906-29-1, Molecule formular: C22H21F3N6O3S, Molecule Weight: 506.5, Chemical name: N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells with PF-431396 blocked anti-Ig-induced tyrosine phosphorylation of Pyk2 and FAK when the cells were stimulated in suspension when they were stimulated on ECM [3]. Nanomolar affinities were also determined for PF-431396 (Kd = 445 ± 42 nM) and for the PIM inhibitor (Kd = 565 ± 63 nM) For the detailed information of PF-431396, the solubility of PF-431396 in water, the solubility of PF-431396 in DMSO, the solubility of PF-431396 in PBS buffer, the animal experiment (test) of PF-431396, the cell expriment (test) of PF-431396, the in vivo, in vitro and clinical trial test of PF-431396, the EC50, IC50,and affinity,of PF-431396, Please contact DC Chemicals.
TBA-354 supplier|TBA354 |DC Chemicals
TBA-354 supplier|TBA354 |DC Chemicals
DC Chemicals provides TBA-354 , other names: TBA 354 ，TBA354 , cas: 1257426-19-9. In stock.
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TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.
TBA-354 , other names: TBA 354 ，TBA354 , cas: 1257426-19-9, Molecule formular: C19H15F3N4O5, Molecule Weight: 436.34, Chemical name:
TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates [1]. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy For the detailed information of TBA-354 , the solubility of TBA-354 in water, the solubility of TBA-354 in DMSO, the solubility of TBA-354 in PBS buffer, the animal experiment (test) of TBA-354 , the cell expriment (test) of TBA-354 , the in vivo, in vitro and clinical trial test of TBA-354 , the EC50, IC50,and affinity,of TBA-354 , Please contact DC Chemicals.
DC Chemicals provides TBA-354 , other names: TBA 354 ，TBA354 , cas: 1257426-19-9. In stock.
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TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.
TBA-354 , other names: TBA 354 ，TBA354 , cas: 1257426-19-9, Molecule formular: C19H15F3N4O5, Molecule Weight: 436.34, Chemical name:
TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates [1]. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy For the detailed information of TBA-354 , the solubility of TBA-354 in water, the solubility of TBA-354 in DMSO, the solubility of TBA-354 in PBS buffer, the animal experiment (test) of TBA-354 , the cell expriment (test) of TBA-354 , the in vivo, in vitro and clinical trial test of TBA-354 , the EC50, IC50,and affinity,of TBA-354 , Please contact DC Chemicals.
CH-223191 supplier|CH223191|DC Chemicals
CH-223191 supplier|CH223191|DC Chemicals
DC Chemicals provides CH-223191, other names: CH223191，CH 223191, cas: 301326-22-7. In stock.
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CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.
CH-223191, other names: CH223191，CH 223191, cas: 301326-22-7, Molecule formular: C19H19N5O, Molecule Weight: 333.39, Chemical name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
CH-223191 preferentially inhibits the ability of some classes of AhR agonists (2,3,7,8-tetrachlorodibenzo-p-dioxin and related HAHs), but not others (PAHs, flavonoids, or indirubin), to bind to and/or activate the AhR and AhR signal transduction [1]. CH-223191 potently inhibits TCDD-induced AhR-dependent transcription. In addition, CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR For the detailed information of CH-223191, the solubility of CH-223191 in water, the solubility of CH-223191 in DMSO, the solubility of CH-223191 in PBS buffer, the animal experiment (test) of CH-223191, the cell expriment (test) of CH-223191, the in vivo, in vitro and clinical trial test of CH-223191, the EC50, IC50,and affinity,of CH-223191, Please contact DC Chemicals.
DC Chemicals provides CH-223191, other names: CH223191，CH 223191, cas: 301326-22-7. In stock.
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CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.
CH-223191, other names: CH223191，CH 223191, cas: 301326-22-7, Molecule formular: C19H19N5O, Molecule Weight: 333.39, Chemical name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
CH-223191 preferentially inhibits the ability of some classes of AhR agonists (2,3,7,8-tetrachlorodibenzo-p-dioxin and related HAHs), but not others (PAHs, flavonoids, or indirubin), to bind to and/or activate the AhR and AhR signal transduction [1]. CH-223191 potently inhibits TCDD-induced AhR-dependent transcription. In addition, CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR For the detailed information of CH-223191, the solubility of CH-223191 in water, the solubility of CH-223191 in DMSO, the solubility of CH-223191 in PBS buffer, the animal experiment (test) of CH-223191, the cell expriment (test) of CH-223191, the in vivo, in vitro and clinical trial test of CH-223191, the EC50, IC50,and affinity,of CH-223191, Please contact DC Chemicals.
SCR7 supplier|SCR-7|DC Chemicals
SCR7 supplier|SCR-7|DC Chemicals
DC Chemicals provides SCR7, other names: SCR7; SCR-7; SCR 7., cas: 1533426-72-0. In stock.
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SCR7 is a specific DNA Ligase IV inhibitor.
SCR7, other names: SCR7; SCR-7; SCR 7., cas: 1533426-72-0, Molecule formular: C18H14N4OS, Molecule Weight: 334.09, Chemical name: 5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis. Notably SCR7 treatment did not result in any adverse effects in mice and did not inhibit Ligase III. The therapeutic efficacy of SCR7 could be enhanced by specific delivery of SCR7 to the tumour tissue and as adjuvant cancer therapy. SCR7 appears to be a potential cytotoxic anti-cancer drug candidate that can be used either alone or in combination with conventional DNA damaging drugs, owing to its specificity and absence of adverse effects in mice model. (source: J. Biosci. 39(3), June 2014, 339–340). (Last updated: 1/30/2015) For the detailed information of SCR7, the solubility of SCR7 in water, the solubility of SCR7 in DMSO, the solubility of SCR7 in PBS buffer, the animal experiment (test) of SCR7, the cell expriment (test) of SCR7, the in vivo, in vitro and clinical trial test of SCR7, the EC50, IC50,and affinity,of SCR7, Please contact DC Chemicals.
DC Chemicals provides SCR7, other names: SCR7; SCR-7; SCR 7., cas: 1533426-72-0. In stock.
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SCR7 is a specific DNA Ligase IV inhibitor.
SCR7, other names: SCR7; SCR-7; SCR 7., cas: 1533426-72-0, Molecule formular: C18H14N4OS, Molecule Weight: 334.09, Chemical name: 5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis. Notably SCR7 treatment did not result in any adverse effects in mice and did not inhibit Ligase III. The therapeutic efficacy of SCR7 could be enhanced by specific delivery of SCR7 to the tumour tissue and as adjuvant cancer therapy. SCR7 appears to be a potential cytotoxic anti-cancer drug candidate that can be used either alone or in combination with conventional DNA damaging drugs, owing to its specificity and absence of adverse effects in mice model. (source: J. Biosci. 39(3), June 2014, 339–340). (Last updated: 1/30/2015) For the detailed information of SCR7, the solubility of SCR7 in water, the solubility of SCR7 in DMSO, the solubility of SCR7 in PBS buffer, the animal experiment (test) of SCR7, the cell expriment (test) of SCR7, the in vivo, in vitro and clinical trial test of SCR7, the EC50, IC50,and affinity,of SCR7, Please contact DC Chemicals.
LFM-A13 supplier|LFMA13|DC Chemicals
LFM-A13 supplier|LFMA13|DC Chemicals
DC Chemicals provides LFM-A13, other names: LFMA13, cas: 244240-24-2. In stock.
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FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).
LFM-A13, other names: LFMA13, cas: 244240-24-2, Molecule formular: C11H8Br2N2O2, Molecule Weight: 360, Chemical name: 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B-cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B-cells by preventing FAS-FADD interaction.1 LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.2,1 It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.2,3 LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.2,3 LFM-A13 also exhibits anti-proliferative activity against Her2/Neu-overexpressing breast cancer cells. For the detailed information of LFM-A13, the solubility of LFM-A13 in water, the solubility of LFM-A13 in DMSO, the solubility of LFM-A13 in PBS buffer, the animal experiment (test) of LFM-A13, the cell expriment (test) of LFM-A13, the in vivo, in vitro and clinical trial test of LFM-A13, the EC50, IC50,and affinity,of LFM-A13, Please contact DC Chemicals.
DC Chemicals provides LFM-A13, other names: LFMA13, cas: 244240-24-2. In stock.
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FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).
LFM-A13, other names: LFMA13, cas: 244240-24-2, Molecule formular: C11H8Br2N2O2, Molecule Weight: 360, Chemical name: 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B-cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B-cells by preventing FAS-FADD interaction.1 LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.2,1 It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.2,3 LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.2,3 LFM-A13 also exhibits anti-proliferative activity against Her2/Neu-overexpressing breast cancer cells. For the detailed information of LFM-A13, the solubility of LFM-A13 in water, the solubility of LFM-A13 in DMSO, the solubility of LFM-A13 in PBS buffer, the animal experiment (test) of LFM-A13, the cell expriment (test) of LFM-A13, the in vivo, in vitro and clinical trial test of LFM-A13, the EC50, IC50,and affinity,of LFM-A13, Please contact DC Chemicals.
BRD73954 supplier|BRD-73954|DC Chemicals
BRD73954 supplier|BRD-73954|DC Chemicals
DC Chemicals provides BRD73954, other names: BRD-73954，BRD 73954, cas: 1440209-96-0. In stock.
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BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.
BRD73954, other names: BRD-73954，BRD 73954, cas: 1440209-96-0, Molecule formular: C16H16N2O3, Molecule Weight: 284.3, Chemical name: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
HDACs are a family of proteins with diverse roles. HDAC6 is a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility.1 HDAC8, on the other hand, is a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression.2,3 BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).4 It is at least 75-fold less effective against other HDAC isoforms.4 At 10 µM, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. For the detailed information of BRD73954, the solubility of BRD73954 in water, the solubility of BRD73954 in DMSO, the solubility of BRD73954 in PBS buffer, the animal experiment (test) of BRD73954, the cell expriment (test) of BRD73954, the in vivo, in vitro and clinical trial test of BRD73954, the EC50, IC50,and affinity,of BRD73954, Please contact DC Chemicals.
DC Chemicals provides BRD73954, other names: BRD-73954，BRD 73954, cas: 1440209-96-0. In stock.
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BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.
BRD73954, other names: BRD-73954，BRD 73954, cas: 1440209-96-0, Molecule formular: C16H16N2O3, Molecule Weight: 284.3, Chemical name: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
HDACs are a family of proteins with diverse roles. HDAC6 is a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility.1 HDAC8, on the other hand, is a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression.2,3 BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).4 It is at least 75-fold less effective against other HDAC isoforms.4 At 10 µM, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. For the detailed information of BRD73954, the solubility of BRD73954 in water, the solubility of BRD73954 in DMSO, the solubility of BRD73954 in PBS buffer, the animal experiment (test) of BRD73954, the cell expriment (test) of BRD73954, the in vivo, in vitro and clinical trial test of BRD73954, the EC50, IC50,and affinity,of BRD73954, Please contact DC Chemicals.
NU1025 supplier|NU 1025|DC Chemicals
NU1025 supplier|NU 1025|DC Chemicals
DC Chemicals provides NU1025, other names: NU 1025，NU 1025, cas: 90417-38-2. In stock.
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NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).
NU1025, other names: NU 1025，NU 1025, cas: 90417-38-2, Molecule formular: C9H8N2O2, Molecule Weight: 176.2, Chemical name: 8-hydroxy-2-methyl-4(3H)-quinazolinone
NU 1025 is a potent PARP-1 (poly(ADP-ribose) polymerase; PARP) inhibitor that has demonstrated the ability to enhance the cytotoxicity of the DNA methylating compound MTIC (sc-211930), bleomycin, and γ-irradiaton. Studies have reported that NU 1025 is 40 to 50 times stronger than benzamide (sc-202494) and 3-aminobenzamide (sc-3501), increases DNA double-strand and single strand breaks, and has neuroprotective effects. Additionally, NU 1025 amplifies the cytotoxic effect of camptothecin (sc-200871), which is a topoisomerase I (Topo I) inhibitor. For the detailed information of NU1025, the solubility of NU1025 in water, the solubility of NU1025 in DMSO, the solubility of NU1025 in PBS buffer, the animal experiment (test) of NU1025, the cell expriment (test) of NU1025, the in vivo, in vitro and clinical trial test of NU1025, the EC50, IC50,and affinity,of NU1025, Please contact DC Chemicals.
DC Chemicals provides NU1025, other names: NU 1025，NU 1025, cas: 90417-38-2. In stock.
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NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).
NU1025, other names: NU 1025，NU 1025, cas: 90417-38-2, Molecule formular: C9H8N2O2, Molecule Weight: 176.2, Chemical name: 8-hydroxy-2-methyl-4(3H)-quinazolinone
NU 1025 is a potent PARP-1 (poly(ADP-ribose) polymerase; PARP) inhibitor that has demonstrated the ability to enhance the cytotoxicity of the DNA methylating compound MTIC (sc-211930), bleomycin, and γ-irradiaton. Studies have reported that NU 1025 is 40 to 50 times stronger than benzamide (sc-202494) and 3-aminobenzamide (sc-3501), increases DNA double-strand and single strand breaks, and has neuroprotective effects. Additionally, NU 1025 amplifies the cytotoxic effect of camptothecin (sc-200871), which is a topoisomerase I (Topo I) inhibitor. For the detailed information of NU1025, the solubility of NU1025 in water, the solubility of NU1025 in DMSO, the solubility of NU1025 in PBS buffer, the animal experiment (test) of NU1025, the cell expriment (test) of NU1025, the in vivo, in vitro and clinical trial test of NU1025, the EC50, IC50,and affinity,of NU1025, Please contact DC Chemicals.
L-006,235 supplier|L-006235|DC Chemicals
L-006,235 supplier|L-006235|DC Chemicals
DC Chemicals provides L-006,235, other names: L-006235, cas: 294623-49-7. In stock.
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L 006235 is a reversible and potent cathepsin K inhibitor that displays more than a 4000 fold selectivity over cathepsins B, L and S.
L-006,235, other names: L-006235, cas: 294623-49-7, Molecule formular: , Molecule Weight: , Chemical name: N-[1-[[(Cyanomethyl)amino]carbonyl] cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazo lyl]benzamide
L-006,235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. For the detailed information of L-006,235, the solubility of L-006,235 in water, the solubility of L-006,235 in DMSO, the solubility of L-006,235 in PBS buffer, the animal experiment (test) of L-006,235, the cell expriment (test) of L-006,235, the in vivo, in vitro and clinical trial test of L-006,235, the EC50, IC50,and affinity,of L-006,235, Please contact DC Chemicals.
DC Chemicals provides L-006,235, other names: L-006235, cas: 294623-49-7. In stock.
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L 006235 is a reversible and potent cathepsin K inhibitor that displays more than a 4000 fold selectivity over cathepsins B, L and S.
L-006,235, other names: L-006235, cas: 294623-49-7, Molecule formular: , Molecule Weight: , Chemical name: N-[1-[[(Cyanomethyl)amino]carbonyl] cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazo lyl]benzamide
L-006,235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. For the detailed information of L-006,235, the solubility of L-006,235 in water, the solubility of L-006,235 in DMSO, the solubility of L-006,235 in PBS buffer, the animal experiment (test) of L-006,235, the cell expriment (test) of L-006,235, the in vivo, in vitro and clinical trial test of L-006,235, the EC50, IC50,and affinity,of L-006,235, Please contact DC Chemicals.
Ro 48-8071 fumarate supplier|Ro 488071 |DC Chemicals
Ro 48-8071 fumarate supplier|Ro 488071 |DC Chemicals
DC Chemicals provides Ro 48-8071 fumarate, other names: Ro 488071 , cas: 189197-69-1. In stock.
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Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
Ro 48-8071 fumarate, other names: Ro 488071 , cas: 189197-69-1, Molecule formular: C27H31BrFNO6, Molecule Weight: 564.44, Chemical name: [4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate
Ro 48-8.071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; in cells it triggered the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol [1]. Ro 48-8071 showed potent noncompetitive inhibition of bacterial squalene:hopene cyclase (SHC) from Alicyclobacillus acidocaldarius (IC50 = 9.0 nM, KI = 6.6 nM) and OSLC (IC50 = 40 nM, KI = 22 nM for homogeneous rat liver OSLC) [2]. Ro 48-8071 dose-dependently inhibited 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC50 value, ~10 μM), under conditions that were non-toxic to the cells. Ro 48-8071 was less effective against ERβ-induced luciferase activity. Androgen receptor (AR) mediated transcriptional activity was also reduced by Ro 48-8071 [ For the detailed information of Ro 48-8071 fumarate, the solubility of Ro 48-8071 fumarate in water, the solubility of Ro 48-8071 fumarate in DMSO, the solubility of Ro 48-8071 fumarate in PBS buffer, the animal experiment (test) of Ro 48-8071 fumarate, the cell expriment (test) of Ro 48-8071 fumarate, the in vivo, in vitro and clinical trial test of Ro 48-8071 fumarate, the EC50, IC50,and affinity,of Ro 48-8071 fumarate, Please contact DC Chemicals.
DC Chemicals provides Ro 48-8071 fumarate, other names: Ro 488071 , cas: 189197-69-1. In stock.
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Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
Ro 48-8071 fumarate, other names: Ro 488071 , cas: 189197-69-1, Molecule formular: C27H31BrFNO6, Molecule Weight: 564.44, Chemical name: [4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate
Ro 48-8.071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; in cells it triggered the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol [1]. Ro 48-8071 showed potent noncompetitive inhibition of bacterial squalene:hopene cyclase (SHC) from Alicyclobacillus acidocaldarius (IC50 = 9.0 nM, KI = 6.6 nM) and OSLC (IC50 = 40 nM, KI = 22 nM for homogeneous rat liver OSLC) [2]. Ro 48-8071 dose-dependently inhibited 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC50 value, ~10 μM), under conditions that were non-toxic to the cells. Ro 48-8071 was less effective against ERβ-induced luciferase activity. Androgen receptor (AR) mediated transcriptional activity was also reduced by Ro 48-8071 [ For the detailed information of Ro 48-8071 fumarate, the solubility of Ro 48-8071 fumarate in water, the solubility of Ro 48-8071 fumarate in DMSO, the solubility of Ro 48-8071 fumarate in PBS buffer, the animal experiment (test) of Ro 48-8071 fumarate, the cell expriment (test) of Ro 48-8071 fumarate, the in vivo, in vitro and clinical trial test of Ro 48-8071 fumarate, the EC50, IC50,and affinity,of Ro 48-8071 fumarate, Please contact DC Chemicals.
TBPB supplier||DC Chemicals
TBPB supplier||DC Chemicals
DC Chemicals provides TBPB, other names: , cas: 634616-95-8. In stock.
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TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
TBPB, other names: , cas: 634616-95-8, Molecule formular: C25H32N4O, Molecule Weight: 404.55, Chemical name:
TBPB activates M(1) through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its unprecedented selectivity. Whole-cell patch-clamp recordings demonstrated that activation of M(1) by TBPB potentiates NMDA receptor currents in hippocampal pyramidal cells but does not alter excitatory or inhibitory synaptic transmission, responses thought to be mediated by M(2) and M(4)。TBPB was efficacious in models predictive of antipsychotic-like activity in rats at doses that did not produce catalepsy or peripheral adverse effects of other mAChR agonists For the detailed information of TBPB, the solubility of TBPB in water, the solubility of TBPB in DMSO, the solubility of TBPB in PBS buffer, the animal experiment (test) of TBPB, the cell expriment (test) of TBPB, the in vivo, in vitro and clinical trial test of TBPB, the EC50, IC50,and affinity,of TBPB, Please contact DC Chemicals.
DC Chemicals provides TBPB, other names: , cas: 634616-95-8. In stock.
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TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
TBPB, other names: , cas: 634616-95-8, Molecule formular: C25H32N4O, Molecule Weight: 404.55, Chemical name:
TBPB activates M(1) through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its unprecedented selectivity. Whole-cell patch-clamp recordings demonstrated that activation of M(1) by TBPB potentiates NMDA receptor currents in hippocampal pyramidal cells but does not alter excitatory or inhibitory synaptic transmission, responses thought to be mediated by M(2) and M(4)。TBPB was efficacious in models predictive of antipsychotic-like activity in rats at doses that did not produce catalepsy or peripheral adverse effects of other mAChR agonists For the detailed information of TBPB, the solubility of TBPB in water, the solubility of TBPB in DMSO, the solubility of TBPB in PBS buffer, the animal experiment (test) of TBPB, the cell expriment (test) of TBPB, the in vivo, in vitro and clinical trial test of TBPB, the EC50, IC50,and affinity,of TBPB, Please contact DC Chemicals.
UNC2025 supplier| UNC-2025|DC Chemicals
UNC2025 supplier| UNC-2025|DC Chemicals
DC Chemicals provides UNC2025, other names: UNC-2025; UNC2025; UNC 2025., cas: 1429881-91-3. In stock.
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UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
UNC2025, other names: UNC-2025; UNC2025; UNC 2025., cas: 1429881-91-3, Molecule formular: C28H40N6O, Molecule Weight: 476.66, Chemical name: (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro?ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. For the detailed information of UNC2025, the solubility of UNC2025 in water, the solubility of UNC2025 in DMSO, the solubility of UNC2025 in PBS buffer, the animal experiment (test) of UNC2025, the cell expriment (test) of UNC2025, the in vivo, in vitro and clinical trial test of UNC2025, the EC50, IC50,and affinity,of UNC2025, Please contact DC Chemicals.
DC Chemicals provides UNC2025, other names: UNC-2025; UNC2025; UNC 2025., cas: 1429881-91-3. In stock.
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UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
UNC2025, other names: UNC-2025; UNC2025; UNC 2025., cas: 1429881-91-3, Molecule formular: C28H40N6O, Molecule Weight: 476.66, Chemical name: (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro?ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. For the detailed information of UNC2025, the solubility of UNC2025 in water, the solubility of UNC2025 in DMSO, the solubility of UNC2025 in PBS buffer, the animal experiment (test) of UNC2025, the cell expriment (test) of UNC2025, the in vivo, in vitro and clinical trial test of UNC2025, the EC50, IC50,and affinity,of UNC2025, Please contact DC Chemicals.
EI-1 supplier|EI1|DC Chemicals
EI-1 supplier|EI1|DC Chemicals
DC Chemicals provides EI-1, other names: EI1，EI 1, cas: 1418308-27-6. In stock.
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EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
EI-1, other names: EI1，EI 1, cas: 1418308-27-6, Molecule formular: C23H26N4O2, Molecule Weight: 390.48, Chemical name: 6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide
EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
IC50 Value: 15±2 nM (EZH2 wild type); 13±3 nM (EZH2 Y641F mutant type) For the detailed information of EI-1, the solubility of EI-1 in water, the solubility of EI-1 in DMSO, the solubility of EI-1 in PBS buffer, the animal experiment (test) of EI-1, the cell expriment (test) of EI-1, the in vivo, in vitro and clinical trial test of EI-1, the EC50, IC50,and affinity,of EI-1, Please contact DC Chemicals.
DC Chemicals provides EI-1, other names: EI1，EI 1, cas: 1418308-27-6. In stock.
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EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
EI-1, other names: EI1，EI 1, cas: 1418308-27-6, Molecule formular: C23H26N4O2, Molecule Weight: 390.48, Chemical name: 6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide
EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
IC50 Value: 15±2 nM (EZH2 wild type); 13±3 nM (EZH2 Y641F mutant type) For the detailed information of EI-1, the solubility of EI-1 in water, the solubility of EI-1 in DMSO, the solubility of EI-1 in PBS buffer, the animal experiment (test) of EI-1, the cell expriment (test) of EI-1, the in vivo, in vitro and clinical trial test of EI-1, the EC50, IC50,and affinity,of EI-1, Please contact DC Chemicals.
YK-4-279 supplier|YK-4279|DC Chemicals
YK-4-279 supplier|YK-4279|DC Chemicals
DC Chemicals provides YK-4-279, other names: YK-4279, cas: 1037184-44-3. In stock.
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YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1.
YK-4-279, other names: YK-4279, cas: 1037184-44-3, Molecule formular: C17H13Cl2NO4, Molecule Weight: 366.2, Chemical name: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one
ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 µM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.1 For the detailed information of YK-4-279, the solubility of YK-4-279 in water, the solubility of YK-4-279 in DMSO, the solubility of YK-4-279 in PBS buffer, the animal experiment (test) of YK-4-279, the cell expriment (test) of YK-4-279, the in vivo, in vitro and clinical trial test of YK-4-279, the EC50, IC50,and affinity,of YK-4-279, Please contact DC Chemicals.
DC Chemicals provides YK-4-279, other names: YK-4279, cas: 1037184-44-3. In stock.
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YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1.
YK-4-279, other names: YK-4279, cas: 1037184-44-3, Molecule formular: C17H13Cl2NO4, Molecule Weight: 366.2, Chemical name: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one
ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 µM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.1 For the detailed information of YK-4-279, the solubility of YK-4-279 in water, the solubility of YK-4-279 in DMSO, the solubility of YK-4-279 in PBS buffer, the animal experiment (test) of YK-4-279, the cell expriment (test) of YK-4-279, the in vivo, in vitro and clinical trial test of YK-4-279, the EC50, IC50,and affinity,of YK-4-279, Please contact DC Chemicals.
2015年3月30日星期一
STF-118804|cas 894187-61-2|Price|Buy|Supplier|DC Chemicals
STF-118804|cas 894187-61-2|Price|Buy|Supplier|DC Chemicals
DC Chemicals supplies: STF-118804,cas: 894187-61-2,Catalog: DC7573,In stock.
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Product name: STF-118804, Synonyms: AGN-PC-0329XY, AKOS001906141, MCULE-5035356713, STF-118804, cas: 894187-61-2, MW: 461.53, Molecule Formula: C25H23N3O4S
STF-118804, cas 894187-61-2, Purity>98%. Best price and quality from DC Chemicals. AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1
STF-118804 reduces the viability of B-ALL cell lines containing MLL chromosomal translations, with IC50 values in the low nanomolar range. In addition, leukemic samples from ?ve pediatric ALL patients are also sensitive to STF-118804 in the low nanomolar range. STF-118804 induces leukemia MV411 cell apoptosis without antecedent cell cycle arrest. [1] STF-118804 (25 mg/kg twice daily, s.c.) improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and effectively depletes leukemia-initiating cells. [1]For the detailed information of STF-118804, the solubility of STF-118804 in water, the solubility of STF-118804 in DMSO, the solubility of STF-118804 in PBS buffer, the animal experiment (test) of STF-118804, the cell expriment (test) of STF-118804, the in vivo, in vitro and clinical trial test of STF-118804, the EC50, IC50,and Affinity of STF-118804, Please contact DC Chemicals.
FIPI|cas 939055-18-2|Price|Buy|Supplier|DC Chemicals
FIPI|cas 939055-18-2|Price|Buy|Supplier|DC Chemicals
DC Chemicals supplies: FIPI,cas: 939055-18-2,Catalog: DC7574,In stock.
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Product name: FIPI, Synonyms: , cas: 939055-18-2, MW: 457.93, Molecule Formula: C23H24FN5O2.HCl
FIPI, cas 939055-18-2, Purity>98%. Best price and quality from DC Chemicals. STF-118804 is a highly specific NAMPT inhibitor.
Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM For PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.For the detailed information of FIPI, the solubility of FIPI in water, the solubility of FIPI in DMSO, the solubility of FIPI in PBS buffer, the animal experiment (test) of FIPI, the cell expriment (test) of FIPI, the in vivo, in vitro and clinical trial test of FIPI, the EC50, IC50,and Affinity of FIPI, Please contact DC Chemicals.
Torcetrapib|cas 262352-17-0|Price|Buy|Supplier|DC Chemicals
Torcetrapib|cas 262352-17-0|Price|Buy|Supplier|DC Chemicals
DC Chemicals supplies: Torcetrapib,cas: 262352-17-0,Catalog: DC7577,In stock.
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Product name: Torcetrapib, Synonyms: CP-529414, 262352-17-0, CP 529414, CP-529,414, (-)-Torcetrapib, Torcetrapib [USAN], CHEBI:49203, Torcetrapib (USAN/INN), cas: 262352-17-0, MW: 600.473329, Molecule Formula: C26H25F9N2O4
Torcetrapib, cas 262352-17-0, Purity>98%. Best price and quality from DC Chemicals. NVP-AAM077 is a potent antagonist for NMDA receptors.
For the detailed information of Torcetrapib, the solubility of Torcetrapib in water, the solubility of Torcetrapib in DMSO, the solubility of Torcetrapib in PBS buffer, the animal experiment (test) of Torcetrapib, the cell expriment (test) of Torcetrapib, the in vivo, in vitro and clinical trial test of Torcetrapib, the EC50, IC50,and Affinity of Torcetrapib, Please contact DC Chemicals.
Exatecan Mesylate|cas 171335-80-1|Price|Buy|Supplier|DC Chemicals
Exatecan Mesylate|cas 171335-80-1|Price|Buy|Supplier|DC Chemicals
DC Chemicals supplies: Exatecan Mesylate,cas: 171335-80-1,Catalog: DC7578,In stock.
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Product name: Exatecan Mesylate, Synonyms: DX 8951, Dx 8951, cas: 171335-80-1, MW: 435.44, Molecule Formula: C25H26FN3O7S
Exatecan Mesylate, cas 171335-80-1, Purity>98%. Best price and quality from DC Chemicals.
Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues.For the detailed information of Exatecan Mesylate, the solubility of Exatecan Mesylate in water, the solubility of Exatecan Mesylate in DMSO, the solubility of Exatecan Mesylate in PBS buffer, the animal experiment (test) of Exatecan Mesylate, the cell expriment (test) of Exatecan Mesylate, the in vivo, in vitro and clinical trial test of Exatecan Mesylate, the EC50, IC50,and Affinity of Exatecan Mesylate, Please contact DC Chemicals.
Didesethylflurazepam|cas 21808-55-9|Price|Buy|Supplier|DC Chemicals
Didesethylflurazepam|cas 21808-55-9|Price|Buy|Supplier|DC Chemicals
DC Chemicals supplies: Didesethylflurazepam,cas: 21808-55-9,Catalog: DC7579,In stock.
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Product name: Didesethylflurazepam, Synonyms: Dealkylflurazepam, Dideethylflurazepam, N,N-Bisdesethylflurazepam, cas: 21808-55-9, MW: 331.7719, Molecule Formula: C17H15ClFN3O
Didesethylflurazepam, cas 21808-55-9, Purity>98%. Best price and quality from DC Chemicals. Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues.
A metabolite of Flurazepam Controlled substance (depressant).For the detailed information of Didesethylflurazepam, the solubility of Didesethylflurazepam in water, the solubility of Didesethylflurazepam in DMSO, the solubility of Didesethylflurazepam in PBS buffer, the animal experiment (test) of Didesethylflurazepam, the cell expriment (test) of Didesethylflurazepam, the in vivo, in vitro and clinical trial test of Didesethylflurazepam, the EC50, IC50,and Affinity of Didesethylflurazepam, Please contact DC Chemicals.
Naxagolide|cas 88058-88-2|Price|Buy|Supplier|DC Chemicals
Naxagolide|cas 88058-88-2|Price|Buy|Supplier|DC Chemicals
DC Chemicals supplies: Naxagolide,cas: 88058-88-2,Catalog: DC7580,In stock.
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Product name: Naxagolide, Synonyms: Naxagolide [INN], PHNO, Naxagolidum [INN-Latin], Naxagolida [INN-Spanish], 88058-88-2, cas: 88058-88-2, MW: 247.33274, Molecule Formula: C15H21NO2
Naxagolide, cas 88058-88-2, Purity>98%. Best price and quality from DC Chemicals. A metabolite of Flurazepam Controlled substance (depressant).
For the detailed information of Naxagolide, the solubility of Naxagolide in water, the solubility of Naxagolide in DMSO, the solubility of Naxagolide in PBS buffer, the animal experiment (test) of Naxagolide, the cell expriment (test) of Naxagolide, the in vivo, in vitro and clinical trial test of Naxagolide, the EC50, IC50,and Affinity of Naxagolide, Please contact DC Chemicals.
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