Elacestrant dihydrochloride|cas 1349723-93-8

Elacestrant dihydrochloride|cas 1349723-93-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: Elacestrant dihydrochloride|Cas Number: 1349723-93-8| Catalog Number: DC10182|Other Nmaes: RAD1901 ihydrochloride; RAD 1901 dihydrochloride; ; RAD-1901dihydrochloride

Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.

Elacestrant dihydrochloride, also known as RAD1901, is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities. Upon oral administration of higher doses of RAD1901, this agent acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the degradation of the receptor. This may inhibit the growth and survival of ER-expressing cancer cells. At lower doses of this agent, RAD1901 acts as a SERM and has estrogen-like effects in certain tissues, which can both reduce hot flashes and protect against bone loss. In addition, RAD1901 is able to cross the blood-brain barrier (BBB).