Tirofiban(L700462;MK383)|cas 144494-65-5| DC Chem|Supplier|Price|Buy  

Tirofiban(L700462;MK383)|cas 144494-65-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Tirofiban(L700462;MK383)|cas 144494-65-5,Purity: >98% ,Cat No. DC7327, In stock.

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Tirofiban(L700462;MK383)|cas 144494-65-5 ,Synonym: Aggrastat; L700462; MK383  ,Chemical name: L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]- ,Molecular Formula: C22H36N2O5S ,MW:440.6

Tirofiban(L700462;MK383), cas 144494-65-5,Purity: >98%, Best Price and quality from DC Chemicals. Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.

Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. [1][2] It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L. [3] Tirofiban (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. [4] When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. [5][6]