GSK1059615|cas 958852-01-1| DC Chem|Supplier|Price|Buy  

GSK1059615|cas 958852-01-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: GSK1059615|cas 958852-01-1,Purity: >98% ,Cat No. DC7326, In stock.

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GSK1059615|cas 958852-01-1 ,Synonym: GSK 1059615; GSK-1059615  ,Chemical name: (Z)-5-((4-(pyridin-4-yl)quinolin-6-yl)methylene)thiazolidine-2,4-dione ,Molecular Formula: C18H11N3O2S ,MW:333.36

GSK1059615, cas 958852-01-1,Purity: >98%, Best Price and quality from DC Chemicals. GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively.

The pyridinylquinoline derivative GSK1059615 is a novel, ATP-competitive, and reversible inhibitor of the class I family of PI3Ks. GSK1059615 inhibits PI3K signaling, induces G1 arrest and apoptosis, especially in breast tumor cells. [2] Data summarized in another review also shows that GSK1059615 inhibits PI3Kα, β, γ and δ, with Ki of 0.42 nM, 0.6 nM, 0.47 nM and 1.7 nM, respectively. [3] Another report shows that GSK1059615 inhibits PI3Kα with IC50 of 2 nM. In T47D and BT474 cancer cells, GSK1059615 inhibits the phosphorylation of Akt at S473, with IC50 of 40 nM. [4] In xenograft mice models of BT474 or HCC1954 breast cancer cells, GSK1059615 (25 mg/kg) effectively inhibits tumor growth. [3]